The PKCb selective inhibitor, enzastaurin HCL (LY317615), suppresses GSK3b phosphorylation, induces apoptosis and suppresses growth of human colon cancer and glioblastoma xenografts

被引：0

作者：

Graff, JR ^{[1
]}

McNulty, AM ^{[1
]}

Hanna, KR ^{[1
]}

Konicek, BW ^{[1
]}

Lynch, RL ^{[1
]}

Bailey, SN ^{[1
]}

Banks, C ^{[1
]}

Capen, A ^{[1
]}

Goode, RL ^{[1
]}

Lewis, JE ^{[1
]}

Sams, L ^{[1
]}

Neubauer, BL ^{[1
]}

Geeganage, S ^{[1
]}

Thornton, D ^{[1
]}

机构：

[1] Eli Lilly & Co, Indianapolis, IN 46285 USA

来源：

ANNALS OF ONCOLOGY | 2005年 / 16卷

关键词：

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

引用

页码：43 / 43

页数：1

共 8 条

[1] The protein kinase Cβ-selective inhibitor, enzastaurin (LY317615.HCI), suppresses signaling through the AKT pathway, induces apoptosis, and suppresses growth of human colon cancer and glioblastoma xenografts
Graff, JR
McNulty, AM
Hanna, KR
Konicek, BW
Lynch, RL
Bailey, SN
Banks, C
Capen, A
Goode, R
Lewis, JE
Sams, L
Huss, KL
Campbell, RM
Iversen, PW
Neubauer, BL
Brown, TJ
Musib, L
Geeganage, S
Thornton, D
CANCER RESEARCH, 2005, 65 (16) : 7462 - 7469
[2] Enzastaurin (LY317615.HCl), a selective PKC beta inhibitor, suppresses human lung cancer cells in vitro and in vivo: a pharmacodynamic study
Chan, Daniel C.
Chen, Victor J.
Zhang Zhiyong
Zheng Di
Dulude, Alexandra
Nakajima, Eji
Helfrich, Barbara
Hirsch, Fred
Clay, Michael P.
Ma, Doreen
Bunn, Paul A., Jr.
JOURNAL OF THORACIC ONCOLOGY, 2007, 2 (08) : S460 - S460
[3] Enzastaurin (LY317615.HCl) suppresses signaling through the PKC and AKT pathways, inducing apoptosis, suppressing tumor-induced angiogenesis and reducing growth of human cancer xenografts
McNulty, Ann M.
Konicek, Bruce W.
Lynch, Rebecca L.
Thornton, Donald
Douglass, Larry
Colligan, Bruce
Carter, Julia H.
Graff, Jeremy R.
CANCER RESEARCH, 2006, 66 (08)
[4] The oral protein-kinase C β inhibitor enzastaurin (LY317615) suppresses signalling through the AKT pathway, inhibits proliferation and induces apoptosis in multiple myeloma cell lines
Neri, Antonino
Marmiroli, Sandra
Tassone, Pierfrancesco
Lombardi, Luigia
Nobili, Lucia
Verdelli, Donata
Civallero, Monica
Cosenza, Maria
Bertacchini, Jessika
Federico, Massimo
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Deliliers, Giorgio Lambertenghi
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LEUKEMIA & LYMPHOMA, 2008, 49 (07) : 1374 - 1383
[5] Enzastaurin (LY317615.HCI) suppresses signaling through the PKC and AKT pathways, inducing apoptosis, suppressing tumor-induced angiogenesis and reducing growth of human cancer xenografts
Graff, J.
McNulty, A.
Parsons, S.
Lewis, J.
Konicek, B.
Banks, C.
Capen, A.
Douglass, L.
Carter, J.
Starling, J.
EJC SUPPLEMENTS, 2006, 4 (12): : 176 - 176
[6] Ethiadin Induces Apoptosis and Suppresses Growth of MCF-7 Breast Cancer Cells by Regulating the Phosphorylation of Glycogen Synthase Kinase 3 Beta (GSK3β)
Ren, Yazhe
Bao, Guangsen
Yang, Hengbin
Cao, Zhangjun
Shao, Zhiyu
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DISCOVERY MEDICINE, 2022, 33 (169) : 55 - 67
[7] LLL12B, a novel small molecule STAT3 inhibitor induces apoptosis and suppresses cell migration and tumor growth in triple-negative breast cancer cells
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Li, Chenglong
Lin, Jiayuh
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[8] LLL12B, a Novel Small-Molecule STAT3 Inhibitor, Induces Apoptosis and Suppresses Cell Migration and Tumor Growth in Triple-Negative Breast Cancer Cells
Pan, Li
Chen, Xiang
Rassool, Feyruz Virgilia
Li, Chenglong
Lin, Jiayuh
BIOMEDICINES, 2022, 10 (08)

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