Complement receptor 2 in the regulation of the immune response

被引：31
|
作者：
Tolnay, M
Tsokos, GC
机构：
[1] Walter Reed Army Med Ctr, Walter Reed Army Inst Res, Dept Clin Physiol, Washington, DC 20307 USA
[2] Uniformed Serv Univ Hlth Sci, Dept Med, Bethesda, MD 20814 USA
来源：
CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY | 1998年 / 88卷 / 02期
关键词：
complement receptor 2; B lymphocytes; immune response;
D O I：
10.1006/clin.1998.4552
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Antigens coated with split products of C3, the result of complement activation, are capable of crosslinking the complement receptor 2 (CR2, CD21) and the antigen receptor on the surface of B cells simultaneously. This dual recognition leads to increased cell proliferation and differentiation and enhanced antibody production. CR2 is also considered to be a regulator of the B cell response to antigen. In this review we summarize the biology of the CR2 and focus on its essential role in generating an effective B cell response to antigenic stimuli. The involvement of CR2 in the pathophysiology of infectious and autoimmune diseases is also discussed. (C) 1998 Academic Press.
引用
收藏
页码：123 / 132
页数：10
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