HETEROCYCLES 49. SYNTHESIS, CHEMICAL BEHAVIOUR AND BIOLOGICAL PROPERTIES OF HETEROCYCLIC CHALCONES. REVIEW FROM OUR RESEARCH

被引：4

作者：

Leonte, Denisa ^{[1
]}

Coman, Fana-Maria ^{[1
]}

Fotso, Ghislain W. ^{[2
]}

Ngadjui, Bonaventure T. ^{[2
,3
]}

Zaharia, Valentin ^{[1
]}

Ngameni, Bathelemy ^{[3
]}

机构：

[1] Iuliu Hatieganu Univ Med & Pharm, Dept Organ Chem, 41 Victor Babes St, RO-400012 Cluj Napoca, Romania

[2] Univ Yaounde I, Dept Organ Chem, POB 812, Yaounde, Cameroon

[3] Univ Yaounde I, Dept Pharmacognosy & Pharmaceut Chem, POB 1364, Yaounde, Cameroon

来源：

FARMACIA | 2021年 / 69卷 / 05期

关键词：

thiazole; chalcone; flavone; flavanone; aurone; BEITRAGE ZUM STUDIUM; ANTICANCER ACTIVITY; SOMMELET-REACTION; THIAZOLE; SERIES; BROMINATION;

D O I：

10.31925/farmacia.2021.5.1

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The synthesis of the natural products analogues has performed a remarkable expansion in recent years, as natural structures have inspired researchers to develop new potential therapeutic agents with improved pharmacological and pharmacokinetic profiles. This review provides an overview on the synthesis, chemical behaviour and biological properties of some already synthesized heterocyclic chalcones bearing thiazole, indole and pyridine moieties. The attention is directed to the reactivity of the alpha,beta-unsaturated ketone system which provides access to new heterocyclic compounds. The structures of chalcones and their cyclisation products that have shown encouraging in vitro antitumour and antifungal properties are highlighted.

引用

页码：821 / 836

页数：16