Effect of CpG oligodeoxynucleotide on the immune response of 28 kDa outer membrane protein of Brucella

被引：1

作者：

Kaushik, P. ^{[1
]}

Singh, D. K. ^{[1
]}

Dayal, S. ^{[2
]}

Kumar, B. ^{[3
]}

Kumar, P. ^{[4
]}

Chaudhuri, P. ^{[5
]}

机构：

[1] Indian Vet Res Inst, Div Vet Publ Hlth, Bareilly, Uttar Pradesh, India

[2] Indian Vet Res Inst, Div Anim Genet & Breeding, Bareilly, Uttar Pradesh, India

[3] Indian Vet Res Inst, Div Vet Bacteriol, Bareilly, Uttar Pradesh, India

[4] Indian Vet Res Inst, Immunol Sect, Bareilly, Uttar Pradesh, India

[5] Indian Vet Res Inst, Div Biotechnol, Bareilly, Uttar Pradesh, India

来源：

JOURNAL OF APPLIED ANIMAL RESEARCH | 2011年 / 39卷 / 01期

关键词：

Brucella; OMP28; antibody isotype; adjuvant; BALB/C MICE; PROTECTION; MELITENSIS; ABORTUS; VACCINE; MOTIFS; INFECTION; ADJUVANTS; EFFICACY; ANTIGEN;

D O I：

10.1080/09712119.2011.565218

中图分类号：

S8 [畜牧、动物医学、狩猎、蚕、蜂];

学科分类号：

0905 ;

摘要：

In order to develop an effective new generation vaccine against brucellosis, it is important to identify and evaluate the immune response of protein antigens of Brucella. It has been demonstrated that 28 kDa outer membrane protein (OMP28) of Brucella induced Th2 type of immune response with predominant IgG1 and suppressed IL-2 production. However, coadministration of CpG oligodeoxynucleotide caused a shift in the immune response of antigen towards Th1 type with predominant IgG2a and upregulated IL-2 production. This suggested that the OMP28 of Brucella may act as a B-cell antigen and may induce Th1 type of immune response on addition of suitable adjuvant.

引用

页码：57 / 60

页数：4

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