Risk of hypomagnesaemia with proton pump inhibitors

A recent international safety advisory has warned of a potential association between prolonged use of proton pump inhibitors (PPIs) and serious hypomagnesaemia-related adverse events such as tetany, seizures, delirium and cardiac arrhythmias. While this occurs rarely, prescribers should be vigilant to PPI-associated hypomagnesaemia. Patients presenting with hypomagnesaemia may require PPI discontinuation.