Acyclic L-threoninol nucleic acid (L-aTNA) with suitable structural rigidity cross-pairs with DNA and RNA

被引：41
|
作者：
Murayama, Keiji [1 ]
Kashida, Hiromu [1 ]
Asanuma, Hiroyuki [1 ]
机构：
[1] Nagoya Univ, Grad Sch Engn, Dept Mol Design & Engn, Chikusa Ku, Nagoya, Aichi 4648603, Japan
来源：
CHEMICAL COMMUNICATIONS | 2015年 / 51卷 / 30期
关键词：
HELIX HANDEDNESS; CHIRAL PNA; ANALOGS; OLIGONUCLEOTIDES; BINDING; PROBES; CONSTRAINT; STABILITY; BACKBONE; FEATURES;
D O I：
10.1039/c4cc09244a
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
We report the hybridization properties of a novel artificial nucleic acid: acyclic L-threoninol nucleic acid (L-aTNA). L-aTNA formed a more stable duplex with DNA and RNA than either D-aTNA or serinol nucleic acid (SNA) as the rigidity of the L-form was more optimal for interaction with natural nucleic acids.
引用
收藏
页码：6500 / 6503
页数：4
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