Melittin-Based Nano-Delivery Systems for Cancer Therapy

被引：41
|
作者：
Wang, Anqi [1 ]
Zheng, Yuan [1 ]
Zhu, Wanxin [1 ]
Yang, Liuxin [1 ]
Yang, Yang [1 ]
Peng, Jinliang [1 ]
机构：
[1] Shanghai Jiao Tong Univ, Sch Pharm, Shanghai 200240, Peoples R China
来源：
BIOMOLECULES | 2022年 / 12卷 / 01期
基金：
中国国家自然科学基金;
关键词：
melittin; hemolysis; stable loading; nano-delivery system; tumor therapy; NF-KAPPA-B; ANTIMICROBIAL PEPTIDE MELITTIN; RESONANCE ENERGY-TRANSFER; CDSE/ZNS QUANTUM DOTS; BEE VENOM; IN-VITRO; HEMOLYTIC-ACTIVITY; CECROPIN-A; MEDIATOR GENERATION; GENE DELIVERY;
D O I：
10.3390/biom12010118
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Melittin (MEL) is a 26-amino acid polypeptide with a variety of pharmacological and toxicological effects, which include strong surface activity on cell lipid membranes, hemolytic activity, and potential anti-tumor properties. However, the clinical application of melittin is restricted due to its severe hemolytic activity. Different nanocarrier systems have been developed to achieve stable loading, side effects shielding, and tumor-targeted delivery, such as liposomes, cationic polymers, lipodisks, etc. In addition, MEL can be modified on nano drugs as a non-selective cytolytic peptide to enhance cellular uptake and endosomal/lysosomal escape. In this review, we discuss recent advances in MEL's nano-delivery systems and MEL-modified nano drug carriers for cancer therapy.
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页数：18
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