STUDY OF STROMAL EXPRESSION OF CD-10 AND ITS CORRELATION WITH CLINICOPATHOLOGICAL PARAMETERS IN CARCINOMA BREAST

Carcinoma breast is the most commonly prevailing neoplasm among women having no geographical variations and the 2ndmost prevalent neoplasmall over the world. With the introduction of Triple test approach a more accurate evaluation was made possible which allows a well-planned management from the consultant.([1,2])Because of the variability of the epithelial component, the histological grade of invasive breast cancer is frequently underestimated in core needle biopsy. The stroma is typically homogeneous throughout the tumour. Also, a significant CD10 stromal positivity has been linked with a higher tumor grade. CD10 is a metallo-proteinase showing its expression in the stroma of innumerable epithelial neoplasms, being associated with the biological-aggressiveness of the tumour. CNB is the preferred approach for assessing breast masses prior to surgery.([3])However, because of the variability of the epithelial component, CNB frequently underestimates the histological grade of invasive breast cancer.([4])There may be false-negative results also. Tumor stroma may contain more predictive information than the tumor's epithelial component and can help in determining prognosis.([5])Cells of the stroma in breast carcinoma may express CD10 which is a zinc-dependent metalloproteinase. It can cleave the matrix and help in tumor invasion and metastasis. CD10 can also cleave doxorubicin leading to resistance to doxorubicin.([6])An association of strong stromal positivity for CD10 with high grade of the tumour has been found.([7]) Assessment of stromal CD10 positivity in small biopsies may thus aid in assessment of prognosis and deciding the treatment.