Effects of AF102B and tacrine on delayed match-to-sample in monkeys

被引：12
|
作者：
O'Neill, J
Fitten, LJ
Siembieda, D
Halgren, E
Kim, E
Fisher, A
Perryman, K
机构：
[1] Dept Vet Affairs Wadsworth Med Ctr, Los Angeles, CA USA
[2] Dept Vet Affairs Sepulveda Med Ctr, Los Angeles, CA USA
[3] Univ Calif Los Angeles, Sch Med, Los Angeles, CA 90024 USA
[4] INSERM, F-13258 Marseille, France
[5] Israel Inst Biol Res, IL-70450 Ness Ziona, Israel
来源：
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY | 1998年 / 22卷 / 04期
关键词：
AF102B; aging; cholinesterase inhibitors; monkey; muscarinic agonists; tacrine; working memory;
D O I：
10.1016/S0278-5846(98)00029-3
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
1. Object working memory, a function which declines in aging and dementia, was tested in young and aged pretrained monkeys using a delayed match-to-sample task. 2. During drug treatment, monkeys were given the mi muscarinic agonist AF102B (0.1-2.1 mg/kg i.m.), the cholinesterase inhibitor tacrine (0.5-2.0 mg/kg p.o.), or vehicle controls in a repeated measures design to assess putative cognitive enhancement. 3. Both agents improved task performance in both young and aged monkeys, AF102B yielding equivalent or greater, and less variable, improvement than tacrine. 4. AF102B may represent a low-toxicity alternative to tacrine for the treatment of age-related memory disorders.
引用
收藏
页码：665 / 678
页数：14
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