Conjugate Addition - SNAr Domino Reaction for the Synthesis of Benzo- or Pyridyl-Fused Lactams and Sultams

被引：7
|
作者：
Norager, Niels Gron [1 ,2 ]
Juhl, Karsten [1 ]
机构：
[1] H Lundbeck & Co AS, Med Chem Res Denmark, DK-2500 Valby, Denmark
[2] Univ Aarhus, Dept Chem, DK-8000 Aarhus C, Denmark
来源：
SYNTHESIS-STUTTGART | 2010年 / 24期
关键词：
bicyclic compounds; domino reactions; heterocycles; Michael addition; nucleophilic aromatic substitution; HETEROCYCLIC SYNTHESIS; ISOQUINOLIN-1(2H)-ONES; DERIVATIVES; FACILE; ROUTE; ACIDS;
D O I：
10.1055/s-0030-1258302
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A versatile domino reaction that can be used for the synthesis of bicyclic benzo- or pyridyl-fused lactam and sultam derivatives is presented, enabling rapid synthesis of a variety of complex structures.
引用
收藏
页码：4273 / 4281
页数：9
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