Recent Advancements in the Synthesis and Chemistry of Benzo-fused Nitrogen- and Oxygen-based Bioactive Heterocycles

被引：9

作者：

Sharma, Ritu ^{[1
]}

Yadav, Ravi K. ^{[1
]}

Sharma, Richa ^{[1
]}

Sahu, Nawal K. ^{[1
]}

Jain, Mukesh ^{[1
]}

Chaudhary, Sandeep ^{[1
,2
]}

机构：

[1] Malaviya Natl Inst Technol, Dept Chem, Lab Organ & Med Chem OMC Lab, Jawaharlal Nehru Marg, Jaipur 302017, India

[2] Natl Inst Pharmaceut Educ & Res, Dept Med Chem, Raebareli NIPER R New Transit Campus, Bijnor Sisendi Rd, Lucknow 226002, Uttar Pradesh, India

来源：

CURRENT TOPICS IN MEDICINAL CHEMISTRY | 2021年 / 21卷 / 17期

关键词：

Benzo-fused; Heterocycles; Bioactive; Benzoxazinones; Spirooxindole; Coumarin; Benzopyran; 2H-indazole; MICROWAVE-ASSISTED SYNTHESIS; DIVERSITY-ORIENTED SYNTHESIS; POT EFFICIENT SYNTHESIS; IN-VITRO ANTIBACTERIAL; MAMMALIAN-CELL CYCLE; ANTIMICROBIAL ACTIVITY; BIOLOGICAL EVALUATION; ANTIFUNGAL ACTIVITY; HIGHLY EFFICIENT; ANTIOXIDANT ACTIVITY;

D O I：

10.2174/1568026621666210715122919

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Since a variety of benzo-fused nitrogen-and oxygen-based bioactive heterocyclic moieties are present in the form of benzoxazinones, spirooxindole-based heterocyclic compounds, coumarin-fused heterocyclic compounds, and 2H-indazoles, this review article briefly describes some of the major advancements and developments in the area of 1,4-benzoxazine-3-ones, 1,4-benzoxazin-2-ones, spiropyrrolidine and spiropyrrolizine-based ring compounds, coumarin-fused compounds, ben-zopyran-fused coumarins and a 2H-indazoles class of bioheterocycles. Thus, keeping in view the medicinal importance of these bioactive benzo-fused heterocycles, special attention has been given to their synthesis as well as medicinal/pharmaceutical properties in detail.

引用

页码：1538 / 1571

页数：34

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