Autologous hematopoietic stem cell transplantation in non-Hodgkin's lymphomas

Early studies on high-dose therapy followed by autologous bone marrow transplantation demonstrated the safety and efficacy of this approach in non-Hodgkin's lymphoma (NHL). As the procedure became easier and safer with the introduction of peripheral blood progenitor cells instead of marrow, the popularity of this procedure declined. In the last decade, autologous hematopoietic stem cell transplantion has played an important role in front-line and salvage treatments of indolent and aggressive NHL.