Improvement of pharmaceutical potential of all-trans retinoic acid with hydroxypropyl-β-cyclodextrin

被引：2

作者：

Takahashi, Keiko ^{[1
]}

Morimoto, Sayo ^{[1
]}

Nakamura, Hiroto ^{[1
]}

Narusawa, Toshiaki ^{[1
]}

Seki, Taizo ^{[2
,4
]}

Ooe, Masahiko ^{[3
,4
]}

Aoi, Keigo ^{[2
]}

Takada, Akiyoshi ^{[3
]}

机构：

[1] Tokyo Polytech Univ, Ctr Nanosci & Technol, Fac Engn, Dept Life Sci & Sustainable Chem, Atsugi Kanagawa 2430297, Japan

[2] Nagoya Univ, Grad Sch Bioagr Sci, Chikusa Ku, Nagoya, Aichi 4648601, Japan

[3] Osaka Univ, Grad Sch Med, Dept Cosmet Med, Suita, Osaka 5650871, Japan

[4] Tokiwa Pharmaceut Co Ltd, Dev Lab, Chuou Ku, Kobe Hyougo 6508521, Japan

来源：

JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY | 2011年 / 70卷 / 3-4期

关键词：

Tretinoin; Hydroxypropyl-beta-cyclodextrin; Skin rejuvenation therapy; Inhibition of side effects; NMR; TOPICAL TRETINOIN; NMR-SPECTROSCOPY; INCLUSION; EFFICACY; COMPLEX;

D O I：

10.1007/s10847-010-9857-6

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

2-Hydroxypropyl-beta-cyclodextrin (HP-beta-CyD) includes all-trans retinoic acid (RA), covering the double-bond area of RA with substituted hydroxypropyl groups on CyD ring, as proved by the nuclear Overhauser effect (NOE) between methylene protons on the hydroxypropyl groups and the proton on RA. The formation of an inclusion complex results in hydrophilicity and stability. The effect of RA/HP-beta-CyD and that of RA without HP-beta-CyD on wrinkle scores and skin elasticity during skin treatment were identical, and the cutaneous stimulus was reduced comparing with RA. The results indicated that the RA/HP-beta-CyD complex should help to realize new approaches in skin rejuvenation therapy.

引用

页码：389 / 396

页数：8

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