New vaccines: challenges of discovery

被引：15
|
作者：
Mahmoud, Adel [1 ]
机构：
[1] Princeton Univ, Mol Biol & Publ Policy, Princeton, NJ 08544 USA
来源：
MICROBIAL BIOTECHNOLOGY | 2016年 / 9卷 / 05期
关键词：
CANCER-IMMUNOTHERAPY; IMMUNOGENICITY; NEOANTIGENS;
D O I：
10.1111/1751-7915.12397
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Vaccines have been a major component of preventing and controlling infectious diseases. The basis for discovery of what protects is reviewed as well as new attempts in utilizing Reverse Vaccinology, RNA-RNA methods and proteome analysis are adding significantly to our knowledge. The challenge of how to define protective and defined components of microbes is still hampering efforts to discover new vaccines. Recent excitement about immunotherapy of cancer opens the way to develop vaccines against multiple malignancies.
引用
收藏
页码：549 / 552
页数：4
相关论文
共 50 条
  • [1] The Challenges Of Developing New Tuberculosis Vaccines
    Barker, Lewellys F.
    Leadman, Annmarie E.
    Clagett, Bartholt
    HEALTH AFFAIRS, 2011, 30 (06) : 1073 - 1079
  • [2] DISCOVERY MAY LEAD TO NEW RABIES VACCINES
    不详
    JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 2020, 256 (02): : 146 - 146
  • [3] Meningococcal conjugate vaccines: new opportunities and new challenges
    Maiden, MCJ
    Spratt, BG
    LANCET, 1999, 354 (9179): : 615 - 616
  • [4] Adjuvanted leptospiral vaccines: Challenges and future development of new leptospirosis vaccines
    Teixeira, Aline F.
    Fernandes, Luis G., V
    Cavenague, Maria F.
    Takahashi, Maria B.
    Santos, Jademilson C.
    Passalia, Felipe J.
    Daroz, Brenda B.
    Kochi, Leandro T.
    Vieira, Monica L.
    Nascimento, Ana L. T. O.
    VACCINE, 2019, 37 (30) : 3961 - 3973
  • [5] Molecular design of vaccines: a new paradigm of challenges
    von Gabain, A.
    INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY, 2009, 299 : 105 - 106
  • [6] Challenges in the research and development of new human vaccines
    Barbosa, T.
    Barral-Netto, M.
    BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH, 2013, 46 (02) : 103 - 108
  • [7] Towards new TB vaccines: What are the challenges?
    Dockrell, Hazel M.
    PATHOGENS AND DISEASE, 2016, 74 (04): : ftw016
  • [8] Challenges in the discovery of new antibacterial agents
    Barbachyn, Michael
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2012, 243
  • [9] Monitoring the impact of vaccines postlicensure: new challenges, new opportunities
    Schuchat, Anne
    Bell, Beth P.
    EXPERT REVIEW OF VACCINES, 2008, 7 (04) : 437 - 456
  • [10] New Decade of Vaccines 1 The next decade of vaccines: societal and scientific challenges
    Moxon, E. Richard
    Siegrist, Claire-Anne
    LANCET, 2011, 378 (9788): : 348 - 359
12345