Narrow mutational signatures drive acquisition of multidrug resistance in the fungal pathogen Candida glabrata

被引：43

作者：

Ksiezopolska, Ewa ^{[1
,2
]}

Angel Schikora-Tamarit, Miquel ^{[1
,2
]}

Beyer, Reinhard ^{[3
,4
]}

Carlos Nunez-Rodriguez, Juan ^{[1
,2
]}

Schuller, Christoph ^{[3
,4
]}

Gabaldon, Toni ^{[1
,2
,5
]}

机构：

[1] Barcelona Supercomp Ctr BSC CNS, Life Sci Dept, Jordi Girona 29, Barcelona 08034, Spain

[2] Barcelona Inst Sci & Technol, Inst Res Biomed IRB Barcelona, Mech Dis Program, Baldiri Reixac 10, Barcelona 08028, Spain

[3] Univ Nat Resources & Life Sci, Vienna BOKU, Inst Microbial Genet, Konrad Lorenz Str 24, A-3430 Tulln An Der Donau, Austria

[4] Univ Nat Resources & Life Sci, Vienna BOKU, Core Facil Bioact Subst Screening & Anal, Konrad Lorenz Str 24, A-3430 Tulln An Der Donau, Austria

[5] Catalan Inst Res & Adv Studies ICREA, Passeig Lluis Co 23, Barcelona 08010, Spain

来源：

CURRENT BIOLOGY | 2021年 / 31卷 / 23期

基金：

欧盟地平线“2020”;

关键词：

AZOLE RESISTANCE; DRUG-RESISTANCE; INVASIVE CANDIDIASIS; READ ALIGNMENT; FLUCONAZOLE; EVOLUTION; ALBICANS; SUSCEPTIBILITY; TRANSPORTER; MECHANISMS;

D O I：

10.1016/j.cub.2021.09.084

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Fungal infections are a growing medical concern, in part due to increased resistance to one or multiple antifungal drugs. However, the evolutionary processes underpinning the acquisition of antifungal drug resistance are poorly understood. Here, we used experimental microevolution to study the adaptation of the yeast pathogen Candida glabrata to fluconazole and anidulafungin, two widely used antifungal drugs with different

引用

页码：5314 / +

页数：24

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