Metabolomics: State-of-the-Art Technologies and Applications on Drosophila melanogaster

被引：6

作者：

Phan Nguyen Thuy An ^{[1
,2
]}

Fukusaki, Eiichiro ^{[1
]}

机构：

[1] Osaka Univ, Grad Sch Engn, Dept Biotechnol, Osaka, Japan

[2] Rhein Westfal TH Aachen, Aachen Biol & Biotechnol ABBt, Inst Appl Microbiol iAMB, Aachen, Germany

来源：

DROSOPHILA MODELS FOR HUMAN DISEASES | 2018年 / 1076卷

关键词：

Drosophila; Metabolomics; Metabolism; State of the art; HIGH-FAT-DIET; ENERGY-METABOLISM; COLD TOLERANCE; GENE-EXPRESSION; LARGE-SCALE; FRUIT-FLY; DATABASE; MODEL; NMR; REVEALS;

D O I：

10.1007/978-981-13-0529-0_14

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Metabolomics is one of the latest "omics" technology concerned with the high-throughput identification and quantification of metabolites, the final products of cellular processes. The revealed data provide an instantaneous snapshot of an organism's metabolic pathways, which can be used to explain its phenotype or physiology. On the other hand, Drosophila has shown its power in studying metabolism and related diseases. At this stage, we have the state-of-the-art knowledge in place: a potential candidate to study cellular metabolism (Drosophila melanogaster) and a powerful methodology for metabolic network decipherer (metabolomics). Yet missing is advanced metabolomics technologies like isotope--assisted metabolomics optimized for Drosophila. In this chapter, we will discuss on the current status and future perspectives in technologies and applications of Drosophila metabolomics.

引用

页码：257 / 276

页数：20

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