The study of metabolic pathways in tumors based on the transcriptome

被引：9
|
作者：
Bono, H [1 ]
Okazaki, Y [1 ]
机构：
[1] Saitama Med Sch, Res Ctr Genom Med, Div Funct Genom & Syst Med, Hidaka, Saitama 3501241, Japan
来源：
SEMINARS IN CANCER BIOLOGY | 2005年 / 15卷 / 04期
关键词：
microarray; gene ontology; metabolic pathway; SV40T; germinoma;
D O I：
10.1016/j.semcancer.2005.04.008
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
DNA microarray technology revolutionized gene-expression analysis in molecular biology to observe patterns of gene expression in genomic scale. We review the biological aspects of genome-wide gene-expression activity in tumors specially focusing on the analysis of enzyme coding genes. First, the methods for analyzing gene-expression data for the study of metabolome in silico are discussed showing SV40T antigen expressing liver tumor data as an example. Next, an application for tumor metabolome analysis utilizing a reference set of gene-expression profiles is shown. (c) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码：290 / 299
页数：10
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