CSF-1 as a regulator of macrophage activation and immune responses

被引：1
|
作者：
Sweet, MJ [1 ]
Hume, DA
机构：
[1] Univ Queensland, Inst Mol Biosci, CRC Chron Inflammatory Dis, St Lucia, Qld 4072, Australia
[2] Univ Queensland, Dept Microbiol Parasitol, St Lucia, Qld 4072, Australia
[3] Univ Queensland, Dept Biochem, St Lucia, Qld 4072, Australia
来源：
ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS | 2003年 / 51卷 / 03期
关键词：
CSF-1; macrophage; lipopolysaccharide; Toll-like receptors; inflammation;
D O I：
暂无
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Macrophage activation is a key determinant of susceptibility and pathology in a variety of inflammatory diseases. The extent of macrophage activation is tightly regulated by a number of pro-inflammatory cytokines (e.g. IFN-gamma, IL-2, GM-CSF, IL-3) and anti-inflammatory cytokines (e.g. IL-4, IL-10, TGF-beta). Macrophage colony-stimulating factor (CSF-1/M-CSF) is a key differentiation, growth and survival factor for monocytes/macrophages and osteoclasts. The role of this factor in regulating macrophage activation is often overlooked. This review will summarize our current understanding of the effects of CSF-1 on the activation state of mature macrophages and its role in regulating immune responses.
引用
收藏
页码：169 / 177
页数：9
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