Low-dose zinc administration as an effective Wilson's disease treatment

被引：7
|
作者：
Najda, J [1 ]
Stella-Holowiecka, B [1 ]
Machalski, M [1 ]
机构：
[1] L Warynski Silesian Med Acad, Clin Dept Internal Dis & Oncol Chemotherapy, PL-40029 Katowice, Poland
来源：
BIOLOGICAL TRACE ELEMENT RESEARCH | 2001年 / 80卷 / 03期
关键词：
Wilson's disease; zinc; copper;
D O I：
10.1385/BTER:80:3:281
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A case of a 11-yr-long Wilson's disease treatment in a 16-yr-old boy with neurologic presentation was analyzed and monitored. In the face of severe symptoms of chelator intolerance, a comparatively low dose of 100 mg of zinc has been administered for the entire 11-yr-long treatment. Considerable improvement of clinical status was achieved, with accompanying regression of central nervous system lesion. The parameters of copper metabolism were normalized with effective urine elimination. The low-dose oral zinc intake proved to be therapeutically effective, eliminating further copper tissue toxicity.
引用
收藏
页码：281 / 284
页数：4
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