The use of desmopressin in mild hemophilia A

被引：19

作者：

Franchini, Massimo ^{[1
]}

Zaffanello, Marco ^{[2
]}

Lippi, Giuseppe ^{[3
]}

机构：

[1] Azienda Osped Univ Parma, Serv Immunoematol & Med Trasfus, Dipartimento Patol & Med Lab, Parma, Italy

[2] Univ Verona, Sez Pediat, Dipartimento Materno Infantile & Biol Genet, I-37100 Verona, Italy

[3] Azienda Osped Univ Parma, UO Diagnost Ematochim, Parma, Italy

来源：

BLOOD COAGULATION & FIBRINOLYSIS | 2010年 / 21卷 / 07期

关键词：

acquired hemophilia A; carriers; desmopressin; mild hemophilia A; tachyphylaxis; VON-WILLEBRAND-DISEASE; FACTOR-VIII; VONWILLEBRANDS DISEASE; MYOCARDIAL-INFARCTION; CLINICAL-EVALUATION; BLEEDING DISORDERS; INTRANASAL SPRAY; NASAL SPRAY; DDAVP; INHIBITORS;

D O I：

10.1097/MBC.0b013e32833c2bb5

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Owing to its ability to raise plasma levels of factor VIII and von Willebrand factor levels, the synthetic vasopressin analogue desmopressin has become the mainstay of treatment for type 1 von Willebrand disease and mild hemophilia A. A long clinical experience with this drug for prevention or treatment of bleedings in these patients has been accumulated over the past 30 years, supporting its hemostatic effectiveness and safety. In this paper, we summarize the current knowledge on the mechanisms of action as well as its biological effects in patients with mild hemophilia A. The results of the most important clinical trials in this setting are also reviewed. Blood Coagul Fibrinolysis 21: 615-619 (c) 2010 Wolters Kluwer Health | Lippincott Williams & Wilkins.

引用

页码：615 / 619

页数：5

共 50 条

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