Otx2, Gbx2 and Fgf8 interact to position and maintain a mid-hindbrain organizer

被引：232
|
作者：
Joyner, AL
Liu, AM
Millet, S
机构：
[1] NYU, Sch Med, Dept Cell Biol, New York, NY 10016 USA
[2] NYU, Sch Med, Howard Hughes Med Inst, New York, NY 10016 USA
[3] NYU, Sch Med, Skirball Inst Biomol Med, Dev Genet Program, New York, NY 10016 USA
来源：
CURRENT OPINION IN CELL BIOLOGY | 2000年 / 12卷 / 06期
关键词：
D O I：
10.1016/S0955-0674(00)00161-7
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
A decade ago, chick-quail transplantation studies demonstrated that the junction between the midbrain and hindbrain has the properties of an organizing center capable of patterning the midbrain and cerebellum. Many of the genes that function to pattern these tissues have been identified and extensively studied. Recent experiments have shown that Otx2, Gbx2 and Fgf8 genes play a major role in the positioning and functioning of this organizing center.
引用
收藏
页码：736 / 741
页数：6
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  • [1] A role for Gbx2 in repression of Otx2 and positioning the mid/hindbrain organizer
    Sandrine Millet
    Kenneth Campbell
    Douglas J. Epstein
    Kasia Losos
    Esther Harris
    Alexandra L. Joyner
    [J]. Nature, 1999, 401 : 161 - 164
  • [2] A role for Gbx2 in repression of Otx2 and positioning the mid/hindbrain organizer
    Millett, S
    Campbell, K
    Epstein, DJ
    Losos, K
    Harris, E
    Joyner, AL
    [J]. NATURE, 1999, 401 (6749) : 161 - 164
  • [3] Gbx2 and Fgf8 are sequentially required for formation of the mid-hindbrain compartment boundary
    Li, James
    Sunmonu, Abimbola
    Guo, Qiuxia
    [J]. DEVELOPMENTAL BIOLOGY, 2008, 319 (02) : 594 - 594
  • [4] Otx2 and Gbx2 are required for refinement and not induction of mid-hindbrain gene expression
    Li, JYH
    Joyner, AL
    [J]. DEVELOPMENT, 2001, 128 (24): : 4979 - 4991
  • [5] Neuroepithelial co-expression of Gbx2 and Otx2 precedes Fgf8 expression in the isthmic organizer
    Garda, AL
    Echevarría, D
    Martínez, S
    [J]. MECHANISMS OF DEVELOPMENT, 2001, 101 (1-2) : 111 - 118
  • [6] Fgf8 and Gbx2 induction concomitant with Otx2 repression is correlated with midbrain-hindbrain fate of caudal prosencephalon
    Hidalgo-Sánchez, M
    Simeone, A
    Alvarado-Mallart, RM
    [J]. DEVELOPMENT, 1999, 126 (14): : 3191 - 3203
  • [7] Pax2, Otx2, Gbx2 and Fgf8 expression in early otic vesicle development
    Hidalgo-Sánchez, M
    Alvarado-Mallart, RM
    Alvarez, IS
    [J]. MECHANISMS OF DEVELOPMENT, 2000, 95 (1-2) : 225 - 229
  • [8] Positioning the isthmic organizer -: where Otx2 and Gbx2 meet
    Simeone, A
    [J]. TRENDS IN GENETICS, 2000, 16 (06) : 237 - 240
  • [9] Differential expression of Otx2, Gbx2, Pax2, and Fgf8 in the developing vestibular and auditory sensory organs
    Sánchez-Calderón, H
    Martín-Partido, G
    Hidalgo-Sánchez, M
    [J]. BRAIN RESEARCH BULLETIN, 2002, 57 (3-4) : 321 - 323
  • [10] Distinct regulators control the expression of the mid-hindbrain organizer signal FGF8
    Weilan Ye
    Maxime Bouchard
    Donna Stone
    Xiaodong Liu
    Francis Vella
    James Lee
    Harukazu Nakamura
    Siew-Lan Ang
    Meinrad Busslinger
    Arnon Rosenthal
    [J]. Nature Neuroscience, 2001, 4 : 1175 - 1181
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