The kinetic resolution of oxazinones by alcoholysis: access to orthogonally protected β-amino acids

被引：4

作者：

Cronin, Sarah A. ^{[1
]}

Connon, Stephen J. ^{[1
]}

机构：

[1] Trinity Coll Dublin, Trinity Biomed Sci Inst, Sch Chem, Dublin, Ireland

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2021年 / 19卷 / 34期

基金：

爱尔兰科学基金会;

关键词：

ENANTIOSELECTIVE SYNTHESIS; ASYMMETRIC-SYNTHESIS; MESO-ANHYDRIDES; ORGANOCATALYSTS; AZLACTONES; PEPTIDES; DESYMMETRIZATION; CYCLOADDITIONS; CISPENTACIN; DERIVATIVES;

D O I：

10.1039/d1ob01306h

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The catalytic, alcoholytic kinetic resolution of oxazinones is reported. A novel, stereochemically dense cinchona alkaloid-based catalyst can facilitate the highly enantiodiscriminatory (S up to 101) ring-opening of oxazinones equipped with electrophilic aryl units to generate orthogonally protected beta-amino acids for the first time.

引用

页码：7348 / 7352

页数：5