Optimizing the dosing regimens for intravascular administrations of oncolytic adenovirus

被引：0
|
作者：
Tsai, V [1 ]
Johnson, DE [1 ]
Schluep, T [1 ]
Quijano, E [1 ]
Wen, SF [1 ]
Ralston, R [1 ]
Demers, GW [1 ]
Ramachandra, M [1 ]
机构：
[1] Canji Inc, San Diego, CA USA
来源：
IMMUNOLOGY 2004: GENOMIC ISSUES, IMMUNE SYSTEM ACTIVATION AND ALLERGY | 2004年
关键词：
D O I：
暂无
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
The objective of this study was to determine the impact of multiple-dose regimens on the activity of the final dose of an oncolytic adenovirus. Groups of tumor-bearing mice were dosed with the oncolytic adenovirus 01/PEME on each of 1, 2, 3, or 4 consecutive days prior to final treatment with a single dose of a different oncolytic adenovirus carrying the reporter gene, dl01/07-luc. Delivery and replication of the dl01/07-luc in the tumor and liver were determined by quantifying virus DNA copies by PCR and reporter gene activity by a luciferase enzymatic assay. Our results showed that there was a regimen-dependent effect after multiple prior intravenous administrations on the biological activity of dl01/07-luc.
引用
收藏
页码：429 / 436
页数：8
相关论文
共 50 条
  • [1] Optimizing erlotinib plus sulindac dosing regimens in a preclinical model of FAP
    Ulusan, Ahmetmursel
    Rajendran, Praveen
    Dashwood, Wan-Mohaiza
    Mohammed, Altaf
    Sei, Shizuko
    Brown, Powel H.
    Vilar-Sanchez, Eduardo
    Dashwood, Roderick H.
    CANCER RESEARCH, 2019, 79 (13)
  • [2] Repeated dosing improves oncolytic rhabdovirus therapy in mice via interactions with intravascular monocytes
    Victor Naumenko
    Jahanara Rajwani
    Madison Turk
    Chunfen Zhang
    Mandy Tse
    Rachelle P. Davis
    Daesun Kim
    Andrea Rakic
    Himika Dastidar
    Shinia Van
    Laura K. Mah
    Esha K. Kaul
    Vladimir P. Chekhonin
    Douglas J. Mahoney
    Craig N. Jenne
    Communications Biology, 5
  • [3] Repeated dosing improves oncolytic rhabdovirus therapy in mice via interactions with intravascular monocytes
    Naumenko, Victor
    Rajwani, Jahanara
    Turk, Madison
    Zhang, Chunfen
    Tse, Mandy
    Davis, Rachelle P.
    Kim, Daesun
    Rakic, Andrea
    Dastidar, Himika
    Van, Shinia
    Mah, Laura K.
    Kaul, Esha K.
    Chekhonin, Vladimir P.
    Mahoney, Douglas J.
    Jenne, Craig N.
    COMMUNICATIONS BIOLOGY, 2022, 5 (01)
  • [4] Biodistribution of Oncolytic Adenovirus After the Injection of Carrier Cells Infected With Oncolytic Adenovirus
    Hamada, Katsuyuki
    Takagi, Kazuko
    Huang, Wenlin
    Itoh, Hiroshi
    Tani, Kenzabro
    Nawa, Akihiro
    MOLECULAR THERAPY, 2014, 22 : S30 - S30
  • [5] Optimizing antibiotic dosing regimens for nosocomial pneumonia: a window of opportunity for pharmacokinetic and pharmacodynamic modeling
    Shen, Yuwei
    Kuti, Joseph L.
    EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY, 2023, 19 (01) : 13 - 25
  • [6] Optimizing NIS-Expression for Oncolytic Adenovirus-Based Radiotherapy and Imaging of Breast Cancer
    Robert, Sacha
    Jacobsen, Kari
    Romanenko, Margarita
    Inoko, Kazuho
    Wilber, Stacey
    LaRocca, Christopher
    Davydova, Julia
    MOLECULAR THERAPY, 2022, 30 (04) : 51 - 52
  • [7] Concepts in Oncolytic Adenovirus Therapy
    Mantwill, Klaus
    Klein, Florian Gerhard
    Wang, Dongbiao
    Hindupur, Sruthi Vasantamadhava
    Ehrenfeld, Maximilian
    Holm, Per Sonne
    Nawroth, Roman
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 22 (19)
  • [8] Oncolytic Adenovirus in Cancer Immunotherapy
    Peter, Malin
    Kuehnel, Florian
    CANCERS, 2020, 12 (11) : 1 - 23
  • [9] Oncolytic adenovirus research and applications
    Kangasniemi, Lotta
    Hemminki, Akseli
    FUTURE VIROLOGY, 2010, 5 (06) : 745 - 761
  • [10] An Oncolytic Adenovirus for Neuroendocrine Tumors
    Leja, J.
    Yu, D.
    Nilsson, B.
    Oberg, K.
    Giandomenico, V.
    Essand, M.
    HUMAN GENE THERAPY, 2011, 22 (10) : A117 - A117
12345