Tityustoxin and toxin-γ:: a comparative study of their effects on acetylcholine release from rat brain cortical slices

被引：0
|
作者：
Massensini, AR
Romano-Silva, MA
Gomez, MV
Moraes-Santos, T
机构：
[1] Univ Fed Minas Gerais, Inst Ciencias Biol, Dept Farmacol, Lab Neurofarmacol, BR-31270901 Belo Horizonte, MG, Brazil
[2] Univ Fed Minas Gerais, FAFAR, Dept Foods, BR-31270901 Belo Horizonte, MG, Brazil
来源：
MEDICAL SCIENCE RESEARCH | 1998年 / 26卷 / 09期
关键词：
acetylcholine release; brain cortex; scorpion toxins; sodium channels;
D O I：
暂无
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Tityustoxin and toxin-gamma are neurotoxins, purified from the venom of scorpion Tityus srrulatus, that act on the voltage-sensitive sodium channel delaying the inactivation or activating the channel, respectively. We have determined and compared the effect of both toxins on the elicited release of acetylcholine from rat brain cortical slices. Tityustoxin showed a linear concentration-dependent effect, but toxin-gamma did not show the same behaviour. Tetrodotoxin 1.2 mu M was able to block the effects of both toxins. Med Sci Res 26:583-584 (C) 1998 Lippincott Williams & Wilkins.
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页码：583 / 584
页数：2
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