Nuclear microprobe investigation of the penetration of ultrafine zinc oxide into intact and tape-stripped human skin

被引：16

作者：

Szikszai, Z. ^{[1
]}

Kertesz, Zs ^{[1
]}

Bodnar, E. ^{[2
]}

Major, I. ^{[1
]}

Borbiro, I. ^{[3
]}

Kiss, A. Z. ^{[1
]}

Hunyadi, J. ^{[2
]}

机构：

[1] Hungarian Acad Sci, Inst Nucl Res, Debrecen, Hungary

[2] Univ Debrecen, Dept Dermatol, Med & Hlth Sci Ctr, Debrecen, Hungary

[3] Abiol Ltd, Debrecen, Hungary

来源：

NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS | 2010年 / 268卷 / 11-12期

基金：

匈牙利科学研究基金会;

关键词：

Ion microscopy; PIXE; STIM; Sunscreens; ZnO nanoparticles; Penetration into human skin; Tape-stripped skin; SCANNING PROTON MICROPROBE; PERCUTANEOUS UPTAKE; TITANIUM-DIOXIDE; NANOPARTICLES; XENOGRAFTS; MICROSCOPY; PERMEATION; ABSORPTION; EFFICACY; PACKAGE;

D O I：

10.1016/j.nimb.2010.02.040

中图分类号：

TH7 [仪器、仪表];

学科分类号：

0804 ; 080401 ; 081102 ;

摘要：

Ultrafine metal oxides, such as titanium dioxide and zinc oxide are widely used in cosmetic and health products like sunscreens. These oxides are potent UV filters and the small particle size makes the product more transparent compared to formulations containing coarser particles. In the present work the penetration of ultrafine zinc oxide into intact and tape-stripped human skin was investigated using nuclear microprobe techniques, such as proton induced X-ray spectroscopy and scanning transmission ion microscopy. Our results indicate that the penetration of ultrafine zinc oxide, in a hydrophobic basis gel with 48 h application time, is limited to the stratum corneum layer of the intact skin. Removing the stratum corneum partially or entirely by tape-stripping did not cause the penetration of the particles into the deeper dermal layers; the zinc particles remained on the surface of the skin. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：2160 / 2163

页数：4

共 20 条

[1] Nuclear microprobe investigation of the penetration of ultrafine zinc oxide into intact and tape-stripped human skin (vol 268, pg 2160, 2010)
Szikszai, Z.
Kertesz, Zs.
Bodnar, E.
Major, I.
Borbiro, I.
Kiss, B.
Kiss, A. Z.
Hunyadi, J.
NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS, 2014, 338 : 145 - 145
[2] Nuclear microprobe investigation of the penetration of ultrafine zinc oxide into human skin affected by atopic dermatitis
Szikszai, Z.
Kertesz, Zs
Bodnar, E.
Borbiro, I.
Angyal, A.
Csedreki, L.
Furu, E.
Szoboszlai, Z.
Kiss, A. Z.
Hunyadi, J.
NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS, 2011, 269 (20): : 2278 - 2280
[3] Assessment of quantum dot penetration into intact, tape-stripped, abraded and flexed rat skin
Zhang, L. W.
Monteiro-Riviere, N. A.
SKIN PHARMACOLOGY AND PHYSIOLOGY, 2008, 21 (03) : 166 - 180
[4] Nuclear microprobe investigation of the penetration of ultrafine zinc oxide into human skin affected by atopic dermatitis (vol 269, pg 2278, 2011)
Szikszai, Z.
Kertesz, Zs.
Bodnar, E.
Borbiro, I.
Kiss, B.
Angyal, A.
Csedreki, L.
Furu, E.
Szoboszlai, Z.
Kiss, A. Z.
Hunyadi, J.
NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS, 2014, 338 : 146 - 146
[5] Ultrastructural alteration of tape-stripped normal human skin after photodynamic therapy
Bartosik, J
Stender, IM
Kobayasi, T
Ågren, MS
EUROPEAN JOURNAL OF DERMATOLOGY, 2004, 14 (02) : 91 - 95
[6] Ex vivo calcium percutaneous eggression in normal and tape-stripped human skin
Jungman, Elsa
Pirot, Fabrice
Maibach, Howard
CUTANEOUS AND OCULAR TOXICOLOGY, 2012, 31 (01) : 1 - 6
[7] Skin-identical lipids versus petrolatum in the treatment of tape-stripped and detergent-perturbed human skin
Lodén, M
Bárány, E
ACTA DERMATO-VENEREOLOGICA, 2000, 80 (06) : 412 - 415
[8] Effects of topical cholesterol, linoleic acid, and synthetic ceramide III, and an equimolar mixture, on UV-induced skin responses in tape-stripped human skin in vivo
Byun, H.
Cho, K.
Lee, M.
Lee, Y.
Lee, S.
Kim, K.
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JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2011, 131 : S110 - S110
[9] Nuclear microprobe study of TiO2-penetration in the epidermis of human skin xenografts
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NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS, 2005, 231 : 280 - 285
[10] Ethyl cellulose nanocarriers and nanocrystals differentially deliver dexamethasone into intact, tape-stripped or sodium lauryl sulfate-exposed ex vivo human skin - assessment by intradermal microdialysis and extraction from the different skin layers
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Hoenzke, Stefan
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JOURNAL OF CONTROLLED RELEASE, 2016, 242 : 25 - 34

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