PCV chemotherapy for recurrent glioblastoma multiforme

被引：76
|
作者：
Kappelle, AC
Postma, TJ
Taphoorn, MJB
Groeneveld, GJ
van den Bent, MJ
van Groeningen, CJ
Zonnenberg, BA
Sneeuw, KCA
Heimans, JJ
机构：
[1] Vrije Univ Amsterdam, Univ Hosp, Dept Neurol, NL-1007 MB Amsterdam, Netherlands
[2] Vrije Univ Amsterdam, Univ Hosp, Dept Med Oncol, NL-1007 MB Amsterdam, Netherlands
[3] Univ Utrecht, Med Ctr, Dept Neurol, Utrecht, Netherlands
[4] Univ Utrecht, Med Ctr, Dept Med Oncol, Utrecht, Netherlands
[5] Univ Rotterdam Hosp, Dr Daniel Den Hoed Canc Ctr, Dept Neurooncol, Rotterdam, Netherlands
[6] Ctr Comprehens Canc, Amsterdam, Netherlands
来源：
NEUROLOGY | 2001年 / 56卷 / 01期
关键词：
D O I：
10.1212/WNL.56.1.118
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
The authors evaluated response, time to progression (TTP), survival, prognostic factors, and toxicity in 63 patients with a recurrent glioblastoma multiforme treated with procarbazine, lomustine, and vincristine (PCV) chemotherapy. Complete and partial response was observed in two (3%) and five patients (8%). In 16 patients (25%), stable disease was observed. Median TTP and survival were 13 and 33 weeks. Age <40 years and Karnofsky Performance Status <greater than or equal to>90 were associated with longer TTP and survival. PCV treatment was generally well tolerated.
引用
收藏
页码：118 / 120
页数：3
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