Copper-catalyzed coupling of arylboronic acids and amines

被引：242
|
作者：
Antilla, JC [1 ]
Buchwald, SL [1 ]
机构：
[1] MIT, Dept Chem, Cambridge, MA 02139 USA
来源：
ORGANIC LETTERS | 2001年 / 3卷 / 13期
关键词：
D O I：
10.1021/ol0160396
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
[GRAPHICS] A general catalytic coupling of arylboronic acids and amines is reported. This room-temperature coupling was realized through the use of catalytic copper(II) acetate, 2,6-lutidine as base, and myristic acid as an additive. Functionalized aniline substrates provided the diarylamine coupling products in good yield (58-91%), A variety of alkylamines were also successfully coupled to give N-alkyl anilines in moderate yield (50-64%).
引用
收藏
页码：2077 / 2079
页数：3
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