IFN-γ production of adult rat astrocytes triggered by TNF-α

被引：30
|
作者：
Xiao, BG [1 ]
Link, H [1 ]
机构：
[1] Huddinge Univ Hosp, Karolinska Inst, Div Neurol, S-14186 Huddinge, Sweden
来源：
NEUROREPORT | 1998年 / 9卷 / 07期
关键词：
astrocytes; ELISPOT; IFN-gamma; immunocytochemistry; TNF-alpha;
D O I：
10.1097/00001756-199805110-00044
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
IFN-gamma plays an important role in modulating inflammatory responses within the CNS. The cell type responsible for IFN-gamma production within the CNS is less well defined. We examined the production and regulation of IFN-gamma by adult rat astrocytes. IFN-gamma was hardly detectable in cultured astrocytes, while addition of TNF-alpha dose-dependently induced IFN-gamma production by astrocytes. No IFN-gamma production by astrocytes could be induced by LPS, IL-10 or TGF-beta 1. TNF-alpha-induced IFN-gamma production by astrocytes was inhibited by treatment of astrocytes with TGF-beta 1, but not IL-10. TNF-alpha induced IFN-gamma production by astrocytes was confirmed by using immunocytochemical staining. The data suggest that astrocyte-derived IFN-gamma induced by TNF-alpha may participate in local immune reactions of the brain in an autocrine and paracrine fashion.
引用
收藏
页码：1487 / 1490
页数：4
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