TGFβ-mediated immunoregulation

被引：0

作者：

Peng, Y ^{[1
]}

Gorelik, L

Laouar, Y

Li, MO

Flavell, RA

机构：

[1] Univ Washington, Dept Rheumatol, Seattle, WA 98106 USA

[2] Biogen Idec Inc, Cambridge, MA 02142 USA

[3] Yale Univ, Sch Med, Immunobiol Sect, New Haven, CT 06520 USA

[4] Yale Univ, Sch Med, Howard Hughes Med Inst, New Haven, CT 06520 USA

来源：

CYTOKINES AS POTENTIAL THERAPEUTIC TARGETS FOR INFLAMMATORY SKIN DISEASES | 2006年 / 56卷

关键词：

D O I：

暂无

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

T cell homeostasis is required for normal immune responses and prevention of pathological responses. Transforming growth factor (TGF) plays an essential role in that regulation. Owing to its broad expression and inhibitory effects on Multiple immune cell types, TGF regulation is complex. Through recent advances in cell-specific targeting of TGF signaling in vivo, the role of TGF beta in T cell regulation is emerging. We demonstrated here a critical role for TGF beta in regulating effector vs regulatory T cell homeostasis.

引用

页码：155 / +

页数：2

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