Effect of environmental fluctuations on the dynamic composition of engineered cartilage: A deterministic model in stochastic environment

Dynamics of extracellular matrix (ECM) deposition and scaffold degradation in cell-polymer constructs have been studied in a random fluctuating environment created due to the applications of growth factors into the in vitro generation of cartilaginous constructs. Existing models of cell-polymer constructs for the design of engineered cartilage have been discussed and then a new deterministic scheme in random environment proposed taking into account the effects of growth factors as the environmental variability in the form of Gaussian white noise. Steady-state probability distribution of each individual component of the ECM in its homeostasis is found explicitly. The computer-simulated results of the model have been discussed and then compared with the data from a variety of scaffold systems and culture conditions.