Novel pH-sensitive drug delivery system based on natural polysaccharide for doxorubicin release

被引：21

作者：

Lu, Dian-xiang ^{[1
]}

Wen, Xian-tao ^{[1
]}

Liang, Jie ^{[1
]}

Zhang, Xing-dong ^{[1
]}

Gu, Zhong-wei ^{[1
]}

Fan, Yu-jiang ^{[1
]}

机构：

[1] Sichuan Univ, Engn Res Ctr Biomat, Natl Engn Res Ctr Biomat, Chengdu 610064, Peoples R China

来源：

CHINESE JOURNAL OF POLYMER SCIENCE | 2008年 / 26卷 / 03期

关键词：

natural polysaccharide; pH-sensitive; nanoparticle drug delivery system; doxorubicin;

D O I：

10.1142/S0256767908003023

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

A novel pH-sensitive nanoparticle drug delivery system (DDS) derived from natural polysaccharide pullulan for doxorubicin (DOX) release was prepared. Pullulan was functionalized by successive carboxymethylization and amidation to introduce hydrazide groups. DOX was then grafted onto pullulan backbone through the pH-sensitive hydrazone bond to form a pullulan/DOX conjugate. This conjugate self-assembled to form nano-sized particles in aqueous solution as a result of the hydrophobic interaction of the DOX. Transmission electron microscope (TEM) and dynamic light scattering (DLS) characterization showed that the nanoparticles were spherical and their size was less than 100 nm. The DOX released from the nanoparticles in a pH-sensitive manner. In vitro cytotoxicity assay indicated the pullulan/DOX nanoparticles showed comparable cytotoxicity effect with free DOX on the 4T1 mouse breast cancer cells.

引用

页码：369 / 374

页数：6

共 50 条

[1] NOVEL pH-SENSITIVE DRUG DELIVERY SYSTEM BASED ON NATURAL POLYSACCHARIDE FOR DOXORUBICIN RELEASE
樊渝江
Chinese Journal of Polymer Science, 2008, (03) : 369 - 374
[2] Polymeric micellar pH-sensitive drug delivery system for doxorubicin
Hruby, M
Konák, C
Ulbrich, K
JOURNAL OF CONTROLLED RELEASE, 2005, 103 (01) : 137 - 148
[3] A Novel pH-sensitive Nanocomposite Based on Graphene Oxide for Improving Doxorubicin Release
Kachousangi, Marziye Javaheri
Shadboorestan, Amir
Shamsian, Azam
Amini, Mohsen
Atyabi, Fatemeh
Ghahremani, Mohammad Hossein
CURRENT DRUG DELIVERY, 2024, 21 (01) : 140 - 153
[4] A pH-Sensitive Nano Drug Delivery System Derived From Pullulan/Doxorubicin Conjugate
Lu, Dianxiang
Wen, Xiantao
Liang, Jie
Gu, Zhongwei
Zhang, Xingdong
Fan, Yujiang
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, 2009, 89B (01) : 177 - 183
[5] A pH-sensitive charge-conversion system for doxorubicin delivery
Guan, Xiuwen
Li, Yanhui
Jiao, Zixue
Chen, Jie
Guo, Zhaopei
Tian, Huayu
Chen, Xuesi
ACTA BIOMATERIALIA, 2013, 9 (08) : 7672 - 7678
[6] Polyurethane/doxorubicin nanoparticles based on electrostatic interactions as pH-sensitive drug delivery carriers
Huang, Dengcheng
Zhou, Yu
Xiang, Yuan
Shu, Meijie
Chen, Hongxiang
Yang, Bing
Liao, Xinghua
POLYMER INTERNATIONAL, 2018, 67 (09) : 1186 - 1193
[7] Mechanisms of drug release in pH-sensitive micelles for tumour targeted drug delivery system: A review
Wang, Zhe
Deng, Xiangping
Ding, Jinsong
Zhou, Wenhu
Zheng, Xing
Tang, Guotao
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2018, 535 (1-2) : 253 - 260
[8] A pH-sensitive gel as a topical drug delivery system
Sun, Y
Liu, JC
Wang, J
23RD INTERNATIONAL SYMPOSIUM ON CONTROLLED RELEASE OF BIOACTIVE MATERIALS, 1996 PROCEEDINGS, 1996, : 775 - 776
[9] pH-sensitive swelling and release behaviors of anionic hydrogels for intelligent drug delivery system
Kim, Bumsang
Shin, Youngchan
JOURNAL OF APPLIED POLYMER SCIENCE, 2007, 105 (06) : 3656 - 3661
[10] pH-Sensitive Biomaterials for Drug Delivery
Zhuo, Shijie
Zhang, Feng
Yu, Junyu
Zhang, Xican
Yang, Guangbao
Liu, Xiaowen
MOLECULES, 2020, 25 (23):

← 1 2 3 4 5 →