Targeting ETV1 in Gastrointestinal Stromal Tumors: Tripping the Circuit Breaker in GIST?

被引：6
|
作者：
Duensing, Anette [1 ,2 ]
机构：
[1] Univ Pittsburgh, Inst Canc, Canc Therapeut Program, Hillman Canc Ctr, Pittsburgh, PA 15213 USA
[2] Univ Pittsburgh, Sch Med, Dept Pathol, Pittsburgh, PA 15213 USA
来源：
CANCER DISCOVERY | 2015年 / 5卷 / 03期
关键词：
KIT; MUTATIONS;
D O I：
10.1158/2159-8290.CD-15-0116
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Summary: Activating mutations in the KIT or PDGFRA receptor tyrosine kinase genes are the key oncogenic drivers in the majority of gastrointestinal stromal tumors (GIST), but novel results now show that aberrant kinase signaling is potentiated by a positive feedback circuit that involves the ETS transcription factor ETV1. Targeting ETV1 can disrupt this circuit and represents a promising new therapeutic approach for the treatment of GISTs. © 2015 American Association for Cancer Research.
引用
收藏
页码：231 / 233
页数：3
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