Blood serum levels of selected biomarkers of oxidative stress among printing workers occupationally exposed to low-levels of toluene and xylene

被引:0
|
作者
Haghighi, Javid Dehghan [1 ]
Hormozi, Maryam [2 ]
Payandeh, Abolfazl [3 ]
机构
[1] Zahedan Univ Med Sci, Sch Med, Dept Community Med, Zahedan, Iran
[2] Zahedan Univ Med Sci, Hlth Promot Res Ctr, Sch Hlth, Dept Occupat Hlth, Zahedan, Iran
[3] Zahedan Univ Med Sci, Infect Dis & Trop Med Res Ctr, Sch Hlth, Resistant TB Inst,Dept Biostat & Epidemiol, Zahedan, Iran
关键词
Occupational exposure; toluene; xylene; oxidative stress; printing workers; antioxidants; ACID; MARKERS; DAMAGE; HSP70;
D O I
10.1177/07482337221092501
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Printing workers (PWs) are exposed to a mixture of solvents, yet the health risks associated with such exposuer are unknown. This study aimed to compare the serum levels of selected biomarkers of oxidative stress among occupationally exposed PWs to low-level of toluene and xylenes and unexposed controls. Associations between levels of such biomarkers and occupational exposures to toluene and xylene were also investigated. Urinary levels of hippuric acid (HA) and methyl hippuric acids (MHAs) as exposure biomarkers of toluene and xylenes, respectively, and serum levels of oxidative stress biomarkers, including total antioxidant capacity (TAC), malondialdehyde (MDA), and the antioxidant enzymes superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx), were measured among the 84 subjects, comprising 44 PWs and 40 unexposed subjects. Mean concentrations of urinary HA and MHAs of PWs showed a significant increase compared with the unexposed controls. Although levels of urinary biomarkers of exposure to toluene (HA) and xylenes (MHAs) were well below the biological exposure indices (BEIs; ACGHI), PWs presented significantly increased serum levels of MDA, and significantly decreased serum activities of SOD and GPx compared to the unexposed controls. However, for serum TAC and CAT activity, no significant difference was observed between the two groups. Correlation analyses indicated that urinary levels of HA and MHAs were positively correlated with MDA levels and negatively correlated with GPx and SOD. Our study suggested that the alterations evidenced in serum levels of MDA, SOD, and GPx could be involved in the oxidative stress caused by co-exposure to low levels of toluene and xylene. Further investigation is needed to clarify the effect of low-level occupational exposure to solvents among PWs.
引用
收藏
页码:299 / 307
页数:9
相关论文
共 50 条
  • [1] SERUM IMMUNOGLOBULIN LEVELS IN WORKERS EXPOSED TO BENZENE, TOLUENE AND XYLENE
    LANGE, A
    ZATONSKI, W
    SMOLIK, R
    SZYMANSKA, J
    INTERNATIONALES ARCHIV FUR ARBEITSMEDIZIN, 1973, 31 (01): : 37 - 44
  • [2] Inflammatory and oxidative stress biomarkers at protein and molecular levels in workers occupationally exposed to crystalline silica
    Peruzzi, Caroline
    Nascimento, Sabrina
    Gauer, Bruna
    Nardi, Jessica
    Sauer, Elisa
    Goethel, Gabriela
    Cestonaro, Larissa
    Fao, Nuryan
    Cattani, Shanda
    Paim, Cristiane
    Souza, Jorge
    Gnoatto, Daniela
    Garcia, Solange Cristina
    ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH, 2019, 26 (02) : 1394 - 1405
  • [3] Inflammatory and oxidative stress biomarkers at protein and molecular levels in workers occupationally exposed to crystalline silica
    Caroline Peruzzi
    Sabrina Nascimento
    Bruna Gauer
    Jessica Nardi
    Elisa Sauer
    Gabriela Göethel
    Larissa Cestonaro
    Nuryan Fão
    Shanda Cattani
    Cristiane Paim
    Jorge Souza
    Daniela Gnoatto
    Solange Cristina Garcia
    Environmental Science and Pollution Research, 2019, 26 : 1394 - 1405
  • [4] HEMATOLOGICAL INDEXES OF PERIPHERAL-BLOOD IN WORKERS OCCUPATIONALLY EXPOSED TO BENZENE, TOLUENE AND XYLENE
    MOSZCZYNSKI, P
    LISIEWICZ, J
    ZENTRALBLATT FUR BAKTERIOLOGIE MIKROBIOLOGIE UND HYGIENE SERIE B-UMWELTHYGIENE KRANKENHAUSHYGIENE ARBEITSHYGIENE PRAVENTIVE MEDIZIN, 1983, 178 (04): : 329 - 339
  • [5] Alterations in serum immunoglobulin levels in workers occupationally exposed to trichloroethylene
    Zhang, Luoping
    Bassig, Bryan A.
    Mora, Joseph L.
    Vermeulen, Roel
    Ge, Yichen
    Curry, John D.
    Hu, Wei
    Shen, Min
    Qiu, Chuangyi
    Ji, Zhiying
    Reiss, Boris
    McHale, Cliona M.
    Liu, Songwang
    Guo, Weihong
    Purdue, Mark P.
    Yue, Fei
    Li, Laiyu
    Smith, Martyn T.
    Huang, Hanlin
    Tang, Xiaojiang
    Rothman, Nathaniel
    Lan, Qing
    CARCINOGENESIS, 2013, 34 (04) : 799 - 802
  • [6] CYTOGENETIC ANALYSIS OF LYMPHOCYTES FROM HOSPITAL WORKERS OCCUPATIONALLY EXPOSED TO LOW-LEVELS OF IONIZING-RADIATION
    BARQUINERO, JF
    BARRIOS, L
    CABALLIN, MR
    MIRO, R
    RIBAS, M
    SUBIAS, A
    EGOZCUE, J
    MUTATION RESEARCH, 1993, 286 (02): : 275 - 279
  • [7] Mediating effect of oxidative stress on blood pressure elevation in workers exposed to low concentrations of benzene, toluene, and xylene (BTX)
    Zhou, Bingxian
    Wu, Qisheng
    Fan, Shiheng
    Su, Zhuna
    Lu, Chunyun
    Peng, Jianye
    Zhang, Nengde
    Jin, Lei
    Yu, Dee
    Zhang, Jing
    SCIENTIFIC REPORTS, 2024, 14 (01):
  • [8] AIRWAY HYPERRESPONSIVENESS IN WORKERS EXPOSED TO LOW-LEVELS OF IRRITANTS
    KREMER, AM
    PAL, TM
    SCHOUTEN, JP
    RIJCKEN, B
    EUROPEAN RESPIRATORY JOURNAL, 1995, 8 (01) : 53 - 61
  • [9] Targeted proteomic scan identifies alteration of serum proteins among workers occupationally exposed to low levels of trichloroethylene
    Hosgood, H. Dean
    Rahman, Mohammad L. L.
    Blansky, Deanna
    Hu, Wei
    Davitt, Meghan
    Wen, Cuiju
    Huang, Yongshun
    Tang, Xiaojiang
    Li, Laiyu
    Smith, Martyn T. T.
    Zhang, Luoping
    Vermeulen, Roel
    Rothman, Nathaniel
    Bassig, Bryan A. A.
    Lan, Qing
    ENVIRONMENTAL AND MOLECULAR MUTAGENESIS, 2022, 63 (8-9) : 423 - 428
  • [10] Circulating levels of selected miRNAs in occupationally cadmium exposed workers of Rajasthan
    Mitra, P.
    Goyal, T.
    Sharma, S.
    Sharma, P.
    CLINICA CHIMICA ACTA, 2022, 530 : S439 - S439