Since the beginning of the COVID-19 pandemic in 2020 caused by SARS-CoV-2, the question of the origin of this virus has been a highly debated issue. Debates have been, and are still, very disputed and often violent between the two main hypotheses: a natural origin through the "spillover" model or a laboratory-leak origin. Tenants of these two options are building arguments often based on the discrepancies of the other theory. The main problem is that it is the initial question of the origin itself which is biased. Charles Darwin demonstrated in 1859 that all species are appearing through a process of evolution, adaptation and selection. There is no determined origin to any animal or plant species, simply an evolutionary and selective process in which chance and environment play a key role. The very same is true for viruses. There is no determined origin to viruses, simply also an evolutionary and selective process in which chance and environment play a key role. However, in the case of viruses the process is slightly more complex because the "environment" is another living organism. Pandemic viruses already circulate in humans prior to the emergence of a disease. They are simply not capable of triggering an epidemic yet. They must evolve in-host, i.e. in-humans, for that. The evolutionary process which gave rise to SARS-CoV-2 is still ongoing with regular emergence of novel variants more adapted than the previous ones. The real relevant question is how these viruses can emerge as pandemic viruses and what the society can do to prevent the future emergence of pandemic viruses.
机构:
Scripps Res Inst, Dept Immunol & Microbiol, La Jolla, CA 92037 USA
Scripps Res Translat Inst, La Jolla, CA 92037 USAScripps Res Inst, Dept Immunol & Microbiol, La Jolla, CA 92037 USA
Andersen, Kristian G.
Rambaut, Andrew
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Univ Edinburgh, Inst Evolutionary Biol, Edinburgh, Midlothian, ScotlandScripps Res Inst, Dept Immunol & Microbiol, La Jolla, CA 92037 USA
Rambaut, Andrew
Lipkin, W. Ian
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Columbia Univ, Mailman Sch Publ Hlth, Ctr Infect & Immun, New York, NY USAScripps Res Inst, Dept Immunol & Microbiol, La Jolla, CA 92037 USA
Lipkin, W. Ian
Holmes, Edward C.
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Univ Sydney, Sch Life & Environm Sci, Marie Bashir Inst Infect Dis & Biosecur, Sydney, NSW, Australia
Univ Sydney, Sch Med Sci, Sydney, NSW, AustraliaScripps Res Inst, Dept Immunol & Microbiol, La Jolla, CA 92037 USA
Holmes, Edward C.
Garry, Robert F.
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Tulane Univ, Sch Med, Dept Microbiol & Immunol, New Orleans, LA 70112 USA
Zalgen Labs, Germantown, MD USAScripps Res Inst, Dept Immunol & Microbiol, La Jolla, CA 92037 USA
机构:
Ist Sci San Raffaele, Div Immunol Transplantat & Infect Dis, Viral Pathogenesis & Biosafety Unit, Via Olgettina, 58, Milan, ItalyIst Sci San Raffaele, Div Immunol Transplantat & Infect Dis, Viral Pathogenesis & Biosafety Unit, Via Olgettina, 58, Milan, Italy
Pagani, Isabel
Ghezzi, Silvia
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Ist Sci San Raffaele, Div Immunol Transplantat & Infect Dis, Viral Pathogenesis & Biosafety Unit, Via Olgettina, 58, Milan, ItalyIst Sci San Raffaele, Div Immunol Transplantat & Infect Dis, Viral Pathogenesis & Biosafety Unit, Via Olgettina, 58, Milan, Italy
Ghezzi, Silvia
Alberti, Simone
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Ist Sci San Raffaele, Div Immunol Transplantat & Infect Dis, Viral Pathogenesis & Biosafety Unit, Via Olgettina, 58, Milan, ItalyIst Sci San Raffaele, Div Immunol Transplantat & Infect Dis, Viral Pathogenesis & Biosafety Unit, Via Olgettina, 58, Milan, Italy
Alberti, Simone
Poli, Guido
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Ist Sci San Raffaele, Div Immunol Transplantat & Infect Dis, Human Immuno Virol HIV Unit, Via Olgettina 58, Milan, Italy
Univ Vita Salute San Raffaele, Sch Med, Via Olgettina 58, Milan, ItalyIst Sci San Raffaele, Div Immunol Transplantat & Infect Dis, Viral Pathogenesis & Biosafety Unit, Via Olgettina, 58, Milan, Italy
Poli, Guido
Vicenzi, Elisa
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Ist Sci San Raffaele, Div Immunol Transplantat & Infect Dis, Viral Pathogenesis & Biosafety Unit, Via Olgettina, 58, Milan, ItalyIst Sci San Raffaele, Div Immunol Transplantat & Infect Dis, Viral Pathogenesis & Biosafety Unit, Via Olgettina, 58, Milan, Italy
Vicenzi, Elisa
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EUROPEAN PHYSICAL JOURNAL PLUS,
2023,
138
(02):