Points to Consider Regarding De-Escalation Surgery in High-Risk Breast Cancer

被引：5
|
作者：
Corso, Giovanni [1 ,2 ,3 ]
Magnoni, Francesca [1 ]
Veronesi, Paolo [1 ,2 ]
机构：
[1] European Inst Oncol IEO, Div Breast Surg, IRCCS, Milan, Italy
[2] Univ Milan, Fac Med, Dept Oncol & Hematooncol, Milan, Italy
[3] European Canc Prevent Org, Milan, Italy
来源：
ANNALS OF SURGICAL ONCOLOGY | 2022年 / 29卷 / 13期
关键词：
GERMLINE MUTATIONS; BRCA2; MUTATIONS; JEWISH WOMEN; CARRIERS; FAMILIES; THERAPY;
D O I：
10.1245/s10434-022-12542-9
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
For women affected by breast cancer who carry germline BRCA1/2 pathogenic variants, the classic standard treatment consists of therapeutic unilateral mastectomy and risk-reducing contralateral mastectomy. However, data from recent literature demonstrate that for women treated with breast-conserving surgery who receive adequate adjuvant treatments, the increased risk of locoregional recurrences and a breast cancer-related prognosis is not significant. This review describes the clinical factors that could help clinicians decide either against or in favor of a more aggressive type of breast cancer surgery.
引用
收藏
页码：8084 / 8089
页数：6
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