Role of NKT cells in the digestive system. II. NKT cells and diabetes

被引：8
|
作者：
Wu, Lan [1 ]
Van Kaer, Luc [1 ]
机构：
[1] Vanderbilt Univ, Sch Med, Dept Microbiol & Immunol, Nashville, TN 37232 USA
来源：
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY | 2007年 / 293卷 / 05期
关键词：
alpha-galactosylceramide; CD1d; glycolipids; immunomodulation; immunotherapy; natural killer T cells; regulatory T cells; Type; 1; diabetes;
D O I：
10.1152/ajpgi.00242.2007
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Natural killer T ( NKT) cells are a subset of regulatory T lymphocytes that recognize glycolipid antigens presented by the major histocompatibility complex class I- related glycoprotein CD1d. NKT cells have been implicated in regulating the progression of Type 1 diabetes ( T1D) in human patients and in an animal model for T1D. In addition, glycolipid agonists of NKT cells have been successful in preventing diabetes in mice, raising enthusiasm for the development of NKT cell- based therapies for T1D.
引用
收藏
页码：G919 / G922
页数：4
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