Silencing of 06-methylguanine DNA methyltransferase (MGMT) increases temozolomide sensitivity in human malignant glioma cell lines

被引：0
|
作者：
Adams, B. [1 ]
Hermisson, M. [1 ]
Naumann, U. [1 ]
Welter, M. [1 ]
机构：
[1] Hertie Inst, Tubingen, Germany
来源：
ONKOLOGIE | 2008年 / 31卷
关键词：
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
引用
收藏
页码：74 / 74
页数：1
相关论文
共 50 条
  • [1] EXPRESSION OF 06-METHYLGUANINE-DNA METHYLTRANSFERASE IN MALIGNANT HUMAN GLIOMA CELL-LINES
    OSTROWSKI, LE
    VONWRONSKI, MA
    BIGNER, SH
    RASHEED, A
    SCHOLD, SC
    BRENT, TP
    MITRA, S
    BIGNER, DD
    CARCINOGENESIS, 1991, 12 (09) : 1739 - 1744
  • [2] A NOVEL AND SPECIFIC INHIBITOR OF MGMT TRANSCRIPTION INCREASES THE SENSITIVITY OF GLIOMA CELL LINES TO TEMOZOLOMIDE TREATMENT
    Lavon, Iris
    Bier, Ariel
    Refael, Miri
    Siegal, Tali
    NEURO-ONCOLOGY, 2009, 11 (06) : 945 - 945
  • [3] O6-methylguanine DNA methyltransferase and p53 status predict temozolomide sensitivity in human malignant glioma cells
    Hermisson, M
    Klumpp, A
    Wick, W
    Wischhusen, J
    Nagel, G
    Roos, W
    Kaina, B
    Weller, M
    JOURNAL OF NEUROCHEMISTRY, 2006, 96 (03) : 766 - 776
  • [4] O6-Methylguanine-DNA Methyltransferase (MGMT) mRNA Expression Predicts Outcome in Malignant Glioma Independent of MGMT Promoter Methylation
    Kreth, Simone
    Thon, Niklas
    Eigenbrod, Sabina
    Lutz, Juergen
    Ledderose, Carola
    Egensperger, Rupert
    Tonn, Joerg C.
    Kretzschmar, Hans A.
    Hinske, Ludwig C.
    Kreth, Friedrich W.
    PLOS ONE, 2011, 6 (02):
  • [5] The role of direct DNA repair gene O6-methylguanine-DNA methyltransferase (MGMT) in high grade malignant glioma
    M Jeru Manoj
    G K Chetan
    KVL Narasinga Rao
    HN Venkatesh
    MK Sibin
    Ch Lavanya
    Molecular Cytogenetics, 7 (Suppl 1)
  • [6] MGMT and p53 status predict temozolomide sensitivity in human malignant glioma cells
    Hermisson, M
    Klumpp, A
    Wick, W
    Wischhusen, J
    Nagel, G
    Roos, W
    Kaina, B
    Weller, M
    NEURO-ONCOLOGY, 2005, 7 (03) : 376 - 376
  • [7] (Z)-butylidenephthalide Restores Temozolomide Sensitivity to Temozolomide-resistant Malignant Glioma Cells by Downregulating Expression of the DNA Repair Enzyme MGMT
    Yen, S. Y.
    Harn, H. J.
    Lin, S. Z.
    Chen, S. R.
    Lin, P. C.
    Syu, F. J.
    Hsieh, D. K.
    Huang, M. H.
    Chiou, T. W.
    EUROPEAN JOURNAL OF CANCER, 2012, 48 : S220 - S221
  • [8] The temozolomide O6-methylguanine-DNA methyltransferase (MGMT) study: A phase II trial to evaluate the effect of low-dose preoperative neoadjuvant temozolomide on brain tumour MGMT activity in glioma patients
    Del Maestro, R. F.
    Siu, V.
    Sadr, M. Seyed
    Alshami, J.
    Sabau, C.
    Sadr, E. Seyed
    Samani, A.
    Assadian, S.
    Greaves, K.
    Pouliot, J.
    JOURNAL OF CLINICAL ONCOLOGY, 2009, 27 (15)
  • [9] GRADED METHYLATION IN THE PROMOTER AND BODY OF THE O-6-METHYLGUANINE DNA METHYLTRANSFERASE (MGMT) GENE CORRELATES WITH MGMT EXPRESSION IN HUMAN GLIOMA-CELLS
    COSTELLO, JF
    FUTSCHER, BW
    TANO, K
    GRAUNKE, DM
    PIEPER, RO
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1994, 269 (25) : 17228 - 17237
  • [10] Targeting human O6-methylguanine DNA methyltransferase (MGMT/AGT) to the mitochondria affords protection against BCNU, temozolomide and MMS
    Xu, Y
    Chen, XM
    Kelley, MR
    CANCER GENE THERAPY, 2003, 10 : S28 - S28
12345