The Hemostatic System in Patients With Type 2 Diabetes With and Without Cardiovascular Disease

被引：23
|
作者：
Verkleij, Chantal J. N. [1 ]
de Bruijn, Roderick E. [2 ]
Meesters, Eelco W. [2 ]
Gerdes, Victor E. A. [2 ,3 ]
Meijers, Joost C. M. [1 ,3 ]
Marx, Pauline F. [1 ]
机构：
[1] Univ Amsterdam, Acad Med Ctr, Dept Expt Vasc Med, NL-1100 DD Amsterdam, Netherlands
[2] Slotervaart Hosp, Dept Internal Med, Amsterdam, Netherlands
[3] Univ Amsterdam, Acad Med Ctr, Dept Vasc Med, NL-1100 DD Amsterdam, Netherlands
来源：
CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS | 2011年 / 17卷 / 06期
关键词：
cardiovascular disease; coagulation; fibrinolysis; hemostasis; type 2 diabetes mellitus; PLASMINOGEN-ACTIVATOR INHIBITOR; VON-WILLEBRAND-FACTOR; 1ST-DEGREE RELATIVES; INSULIN; PLASMA; NIDDM; COMPLICATIONS; COAGULATION; FIBRINOGEN; RISK;
D O I：
10.1177/1076029610384112
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The contribution of the hemostatic system in the development of cardiovascular disease (CVD) in patients with type 2 diabetes is not completely defined. The aim of this study was to elucidate associations of hemostatic factors with the development of CVD in patients with type 2 diabetes. Patients with type 2 diabetes without CVD (n = 113), with CVD (n = 94), and controls without CVD (n = 100) were enrolled in this study. Several hemostatic markers were measured. A disturbed hemostatic balance in patients with type 2 diabetes was observed as illustrated by hypofibrinolysis and increased levels of von Willebrand factor (vWF) and plasminogen-activator inhibitor 1 (PAI-1). Patients with type 2 diabetes with CVD have more thrombin generation compared to patients without CVD. This hemostatic imbalance might contribute to the development of CVD in patients with type 2 diabetes.
引用
收藏
页码：E57 / E63
页数：7
相关论文
共 50 条
  • [1] The hemostatic system in patients with type 2 diabetes with and without cardiovascular disease
    Verkleij, C. J. N.
    Gerdes, V. E. A.
    de Bruijn, R.
    Meijers, J. C. M.
    Marx, P. F.
    [J]. JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2009, 7 : 739 - 739
  • [2] Incidence of depression in type 2 diabetes patients with and without cardiovascular disease
    Zareini, B.
    Soerensen, K. K. S.
    Blanche, P. B.
    Falkentoft, A. C. F.
    Fosboel, E. F.
    Koeber, L. K.
    Torp-Pedersen, C. T. P.
    [J]. EUROPEAN HEART JOURNAL, 2023, 44
  • [3] Endothelial hemostatic markers in type 2 diabetes and without diabetes in patients with advanced peripheral arterial disease
    Kotschy, Daniel
    Kotschy, Maria
    Socha, Pawel
    Kwapisz, Justyna
    Zuk, Natalia
    Dubis, Joanna
    Karczewski, Maciej
    Witkiewicz, Wojciech
    [J]. CLINICAL DIABETOLOGY, 2014, 3 (06): : 238 - 245
  • [4] Achievement of cardiovascular goals in patients diagnosed with type 2 diabetes with and without cardiovascular disease
    Garzon, Gerardo
    Gil, Angel
    Maria Herrero, Ana
    Jimenez, Fernando
    Jose Cerezo, Maria
    Dominguez, Cristina
    [J]. GACETA SANITARIA, 2015, 29 (06) : 425 - 430
  • [5] Cardiovascular disease in patients with type 2 diabetes
    Jeon, Ja Young
    Kim, Dae Jung
    [J]. JOURNAL OF DIABETES INVESTIGATION, 2022, 13 (04) : 614 - 616
  • [6] Inadequate attainment of lipid levels in patients with or without type 2 diabetes and/or cardiovascular disease
    Nichols, G. A.
    Ambegaonkar, B. M.
    Sazonov, V.
    Brown, J. B.
    [J]. DIABETOLOGIA, 2008, 51 : S559 - S559
  • [7] Differential vascular effects of aspirin in patients with type 2 diabetes without cardiovascular disease and matched controls without diabetes
    Vernstrom, L.
    Laugesen, E.
    Grove, E. L.
    Baier, J. M.
    Gullaksen, S.
    Hvas, A. -M.
    Poulsen, P. L.
    Funck, K. L.
    [J]. DIABETOLOGIA, 2019, 62 : S558 - S558
  • [8] Prevention of cardiovascular disease in patients with type 2 diabetes
    Lebherz, Corinna
    Lehrke, Michael
    [J]. DEUTSCHE MEDIZINISCHE WOCHENSCHRIFT, 2015, 140 (09) : 645 - U16
  • [9] Risk of Cardiovascular Events in Patients With Type 2 Diabetes and Metabolic Dyslipidemia Without Prevalent Atherosclerotic Cardiovascular Disease
    Rana, Jamal S.
    Liu, Jennifer Y.
    Moffet, Howard H.
    Sanchez, Robert J.
    Khan, Irfan
    Karter, Andrew J.
    [J]. AMERICAN JOURNAL OF MEDICINE, 2020, 133 (02): : 200 - 206
  • [10] Comorbidities in type 2 diabetes patients with and without atherosclerotic cardiovascular disease: a retrospective database analysis
    Iglay, Kristy
    Hannachi, Hakima
    Engel, Samuel S.
    Li, Xueying
    O'Connell, David
    Moore, Lori M.
    Rajpathak, Swapnil
    [J]. CURRENT MEDICAL RESEARCH AND OPINION, 2021, 37 (05) : 743 - 751
12345