Functional analysis of β-secretase using mutagenesis and structural homology modeling

被引:0
|
作者
Tatsuno, G [1 ]
Anderson, J [1 ]
Hong, J [1 ]
Agard, DA [1 ]
Ota, N [1 ]
Sinha, S [1 ]
Basi, G [1 ]
McConlogue, L [1 ]
机构
[1] Elan Pharmaceut, S San Francisco, CA 94080 USA
关键词
D O I
10.1002/0470846453.ch74
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
引用
收藏
页码:799 / 807
页数:9
相关论文
共 50 条
  • [1] The role of homology modeling on improving associations between functional and structural mutation using structural based network analysis
    Luo, Yuyang
    Hauser, Blake M.
    Rossin, Elizabeth
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2023, 64 (08)
  • [2] Homology Modeling of VEGF-D as a Basis for Structural and Functional Analysis
    Viitanen, Lenita
    Toivanen, Pyry I.
    Nieminen, Tiina
    Alitalo, Annamari
    Roschier, Miia
    Jauhiainen, Suvi
    Markkanen, Johanna E.
    Laitinen, Olli H.
    Airenne, Tomi T.
    Salminen, Tiina A.
    Johnson, Mark S.
    Airenne, Kari J.
    Yla-Herttuala, Seppo
    ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES, 2009, 65 : S162 - S162
  • [3] Active site analysis of fructosyl amine oxidase using homology modeling and site-directed mutagenesis
    Seiji Miura
    Stefano Ferri
    Wakako Tsugawa
    Seungsu Kim
    Koji Sode
    Biotechnology Letters, 2006, 28 : 1895 - 1900
  • [4] Active site analysis of fructosyl amine oxidase using homology modeling and site-directed mutagenesis
    Miura, Seiji
    Ferri, Stefano
    Tsugawa, Wakako
    Kiin, Seungsu
    Sode, Koji
    BIOTECHNOLOGY LETTERS, 2006, 28 (23) : 1895 - 1900
  • [5] Architecture of P2Y nucleotide receptors: Structural comparison based on sequence analysis, mutagenesis, and homology modeling
    Costanzi, S
    Mamedova, L
    Gao, ZG
    Jacobson, KA
    JOURNAL OF MEDICINAL CHEMISTRY, 2004, 47 (22) : 5393 - 5404
  • [6] Structural and functional characterization of the aryl hydrocarbon receptor ligand binding domain by homology modeling and mutational analysis
    Pandini, Alessandro
    Denison, Michael S.
    Song, Yujuan
    Soshilov, Anatoly A.
    Bonati, Laura
    BIOCHEMISTRY, 2007, 46 (03) : 696 - 708
  • [7] Homology modeling and structural analysis of human P-glycoprotein
    Yamaguchi, Hideaki
    Kidachi, Yumi
    Kamiie, Katsuyoshi
    Noshita, Toshiro
    Umetsu, Hironori
    BIOINFORMATION, 2012, 8 (22) : 1066 - 1074
  • [8] Structural insights into the ATP binding pocket of the anaplastic lymphoma kinase by site-directed mutagenesis, inhibitor binding analysis, and homology modeling
    Gunby, Rosalind H.
    Ahmed, Shaheen
    Sottocornola, Roberta
    Gasser, Marc
    Redaelli, Sara
    Mologni, Luca
    Tartari, Carmen J.
    Belloni, Valentina
    Gambacorti-Passerini, Carlo
    Scapozza, Leonardo
    JOURNAL OF MEDICINAL CHEMISTRY, 2006, 49 (19) : 5759 - 5768
  • [9] Physicochemical characterization, structural analysis and homology modeling of bacterial and fungal laccases using in silico methods
    Tamboli A.S.
    Rane N.R.
    Patil S.M.
    Biradar S.P.
    Pawar P.K.
    Govindwar S.P.
    Network Modeling Analysis in Health Informatics and Bioinformatics, 2015, 4 (1) : 1 - 12
  • [10] Homology modeling and structural analysis of 11β-hydroxysteroid dehydrogenase type 2
    Yamaguchi, Hideaki
    Akitaya, Tatsuo
    Yu, Tao
    Kidachi, Yumi
    Kamiie, Katsuyoshi
    Noshita, Toshiro
    Umetsu, Hironori
    Ryoyama, Kazuo
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2011, 46 (04) : 1325 - 1330