Spatial Memory in the Progeny of Rats Subjected to Different Types of Experimental Preeclampsia

被引：1
|
作者：
Perfilova, V. N. [1 ]
Zhakupova, G. A. [1 ]
Lashchenova, L. I. [1 ]
Lebedeva, S. A. [2 ]
Tyurenkov, I. N. [1 ]
机构：
[1] Volgograd State Med Univ, Volgograd, Russia
[2] Volgograd State Med Univ, Res Inst Pharmacol, Volgograd, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2016年 / 161卷 / 05期
关键词：
experimental preeclampsia; spatial memory;
D O I：
10.1007/s10517-016-3475-2
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Spatial memory was studied in 2-month-old offspring of rats subjected to different types of experimental preeclampsia (replacement of drinking water with 1.8% NaCl from day 1 to 21 of gestation or intraperitoneal administration of non-selective NO-synthase inhibitor L-NAME to pregnant rats in a daily dose of 25 mg/kg for 7 days on gestation days 14-20). Spatial memory was evaluated in an elevated 8-arm radial maze. Both types of experimental preeclampsia impaired spatial (long-term and short-term) memory and can be used in the development of drugs correcting negative effects of this pregnancy complication on memory.
引用
收藏
页码：643 / 646
页数：4
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