Regional inactivations of primate ventral prefrontal cortex reveal two distinct mechanisms underlying negative bias in decision making

被引:37
|
作者
Clarke, Hannah F. [1 ,2 ]
Horst, Nicole K. [2 ,3 ]
Roberts, Angela C. [1 ,2 ]
机构
[1] Univ Cambridge, Dept Physiol Dev & Neurosci, Cambridge CB2 3DY, Cambs, England
[2] Univ Cambridge, Behav & Clin Neurosci Inst, Cambridge CB2 3EB, Cambs, England
[3] Univ Cambridge, Dept Psychol, Cambridge CB2 3EB, Cambs, England
基金
英国惠康基金; 英国医学研究理事会;
关键词
anxiety; orbitofrontal cortex; ventrolateral prefrontal cortex; negative bias; AMYGDALA-HIPPOCAMPAL CONNECTIVITY; MONKEY CALLITHRIX-JACCHUS; ORBITOFRONTAL CORTEX; RHESUS-MONKEYS; FUNCTIONAL CONNECTIVITY; REINFORCER DEVALUATION; CINGULATE CORTEX; ANXIETY; LESIONS; MODULATION;
D O I
10.1073/pnas.1422440112
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Dysregulation of the orbitofrontal and ventrolateral prefrontal cortices is implicated in anxiety and mood disorders, but the specific contributions of each region are unknown, including how they gate the impact of threat on decision making. To address this, the effects of GABAergic inactivation of these regions were studied in marmoset monkeys performing an instrumental approach-avoidance decision-making task that is sensitive to changes in anxiety. Inactivation of either region induced a negative bias away from punishment that could be ameliorated with anxiolytic treatment. However, whereas the effects of ventrolateral prefrontal cortex inactivation on punishment avoidance were seen immediately, those of orbitofrontal cortex inactivation were delayed and their expression was dependent upon an amygdala-anterior hippocampal circuit. We propose that these negative biases result from deficits in attentional control and punishment prediction, respectively, and that they provide the basis for understanding how distinct regional prefrontal dysregulation contributes to the heterogeneity of anxiety disorders with implications for cognitive-behavioral treatment strategies.
引用
收藏
页码:4176 / 4181
页数:6
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