Sterilizing Effects of Novel Regimens Containing TB47, Clofazimine, and Linezolid in a Murine Model of Tuberculosis

被引：11
|
作者：
Yu, Wei [1 ,2 ,3 ]
Yusuf, Buhari [1 ,2 ,3 ]
Wang, Shuai [1 ,2 ,3 ]
Tian, Xirong [1 ,2 ,4 ]
Hameed, H. M. Adnan [1 ,2 ]
Lu, Zhili [1 ,2 ]
Chiwala, Gift [1 ,2 ,3 ]
Alam, Md Shah [1 ,2 ,3 ]
Cook, Gregory M. [6 ,7 ]
Maslov, Dmitry A. [8 ]
Zhong, Nanshan [2 ,5 ]
Zhang, Tianyu [1 ,2 ,3 ]
机构：
[1] Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, State Key Lab Resp Dis, Guangzhou, Peoples R China
[2] Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, Guangdong Hong Kong Macao Joint Lab Resp Infect D, Guangzhou, Peoples R China
[3] Univ Chinese Acad Sci, Beijing, Peoples R China
[4] Anhui Univ, Inst Phys Sci & Informat Technol, Hefei, Peoples R China
[5] Guangzhou Med Univ, Affiliated Hosp 1, Natl Ctr Resp Med, State Key Lab Resp Dis,Natl Clin Res Ctr Resp Dis, Guangzhou, Peoples R China
[6] Univ Otago, Sch Biomed Sci, Dept Microbiol & Immunol, Dunedin, New Zealand
[7] Univ Auckland, Maurice Wilkins Ctr Mol Biodiscovery, Auckland, New Zealand
[8] Russian Acad Sci, Vavilov Inst Gen Genet, Lab Bacterial Genet, Moscow, Russia
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2021年 / 65卷 / 10期
基金：
中国国家自然科学基金; 俄罗斯科学基金会;
关键词：
tuberculosis; cytochrome bc(1)-aa(3) oxidase; TB47; murine model; drug resistance; RESISTANT MYCOBACTERIUM-TUBERCULOSIS; PYRAZINAMIDE RESISTANCE;
D O I：
10.1128/AAC.00706-21
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
TB47, a new drug candidate targeting QcrB in the electron transport chain, has shown a unique synergistic activity with clofazimine and forms a highly sterilizing combination. Here, we investigated the sterilizing effects of several all-oral regimens containing TB47 plus clofazimine and linezolid as a block and the roles of fluoroquinolones and pyrazinamide in them. All these regimens cured tuberculosis within 4 to 6 months in a well-established mouse model, and adding pyrazinamide showed a significant difference in bactericidal effects.
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页数：5
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