Essential oil from the leaves of Xylopia langsdorfiana (Annonaceae) as a possible spasmolytic agent

被引：6
|
作者：
Correia, Ana Carolina de C. [1 ]
Ferreira, Tamyris F. [1 ]
Martins, Italo Rossi R. [1 ]
Macedo, Ciberio L. [1 ]
Monteiro, Fabio de S. [1 ]
Costa, Vicente Carlos O. [1 ]
Tavares, Josean F. [1 ,2 ]
Silva, Marcelo S. [1 ,2 ]
Paredes-Gamero, Edgar J. [3 ]
Buri, Marcus V. [3 ]
Rigoni, Vera L. S. [4 ]
Nouailhetas, Viviane L. A. [4 ]
Da Silva, Bagnolia A. [1 ,2 ]
机构：
[1] Fed Univ Paraiba UFPB, Ctr Hlth Sci CCS, BR-58051970 Joao Pessoa, Paraiba, Brazil
[2] Dept Pharmaceut Sci DCF CCS UFPB, BR-58051970 Joao Pessoa, Paraiba, Brazil
[3] Fed Univ Sao Paulo UNIFESP, Dept Biochem, Sao Paulo, Brazil
[4] Fed Univ Sao Paulo UNIFESP, Dept Biophys, Sao Paulo, Brazil
来源：
NATURAL PRODUCT RESEARCH | 2015年 / 29卷 / 10期
关键词：
Annonaceae; smooth muscle; antispasmodic; calcium; essential oil; GUINEA-PIG ILEUM; A; ST-HIL; ENT-7-ALPHA-ACETOXYTRACHYLOBAN-18-OIC ACID; ENT-7-ALPHA-HYDROXYTRACHYLOBAN-18-OIC ACID; CHEMICAL-COMPOSITION; TUL; ANNONACEAE; SMOOTH-MUSCLE; CALCIUM; CONSTITUENTS;
D O I：
10.1080/14786419.2014.964706
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Xylopia langsdorfiana A. St.-Hil. &Tul. (Annonaceae) is popularly known in the northeast of Brazil as pimenteira da terra', and an essential oil (XL-OE) was extracted from its leaves. Since Xylopia species are cited in folk medicine and diterpenes from X. langsdorfiana have spasmolytic activity, this study aimed to investigate a possible spasmolytic action of XL-OE on smooth muscle models. XL-OE (243 and 729g/mL) showed low pharmacologic efficacy on guinea pig trachea and rat aorta and uterus. However, in guinea pig ileum, XL-OE (27-729g/mL) inhibited carbachol or histamine-induced phasic contractions (1M) in a significant and concentration-dependent manner. In addition, XL-OE (81g/mL) reduced fluorescence intensity in ileal myocytes stimulated by histamine, indicating a decrease in cytosolic calcium concentration, which could explain the spasmolytic activity. Thus, XL-OE proved to be a promising natural product to be used in gastrointestinal diseases acting by modulating the cytosolic calcium concentration.
引用
收藏
页码：980 / 984
页数：5
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