RETRACTED: Expression of miR-711 and mechanism of proliferation and apoptosis in human gastric carcinoma (Retracted article. See vol. 15, pg. 4040, 2018)

被引：7

作者：

Zhu, Sheng-Xing ^{[1
,2
]}

Tong, Xian-Zhou ^{[2
]}

Zhang, Shuijun ^{[1
]}

机构：

[1] Zhengzhou Univ, Affiliated Hosp 1, Dept Gen Surg, 1 Jianshe East Rd, Zhengzhou 450000, Henan, Peoples R China

[2] Peoples Hosp Zhengzhou, Dept Gen Surg 2, Zhengzhou 450000, Henan, Peoples R China

来源：

ONCOLOGY LETTERS | 2017年 / 14卷 / 04期

关键词：

miR-711; apoptosis; gastic carcinoma; CANCER; BCL-2; MICRORNAS; CELLS; RISK;

D O I：

10.3892/ol.2017.6777

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

MicroRNAs (miRs) are involved in many aspects of cell biology, including cell proliferation and apoptosis, two critical aspects of tumor biology. We investigated the effect of miR-711 on Bcl-2 expression in human MGC803 gastric cancer cells and the mechanism of cell proliferation, apoptosis, and invasion. Expression of miR-711 and Bcl-2 was significantly increased in gastric adenocarcinoma compared to adjacent normal tissue. Inhibition of miR-711 in MGC803 gastric cancer cells decreased the expression of Bcl-2, decreased cell proliferation, decreased the invasion ability, and increased apoptosis. The expression of Bcl-2 protein correlated with clinical staging, lymph node metastasis, and tumor differentiation in patients with gastric cancer. The expression of miR-711 positively correlated with the expression of Bcl-2, suggesting that miR-711 and Bcl-2 are co-regulated and involved in the development of gastric cancer.

引用

页码：4505 / 4510

页数：6

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