Combinatorial Antigen Targeting: Ideal T-Cell Sensing and Anti-Tumor Response

被引：8
|
作者：
Themelil, Maria [1 ]
Sadelain, Michel [2 ,3 ]
机构：
[1] Vrije Univ Amsterdam Med Ctr, Canc Ctr Amsterdam, Dept Hematol, NL-1081 HV Amsterdam, Netherlands
[2] Mem Sloan Kettering Canc Ctr, Ctr Cell Engn, New York, NY 10065 USA
[3] Mem Sloan Kettering Canc Ctr, Program Immunol, New York, NY 10065 USA
来源：
TRENDS IN MOLECULAR MEDICINE | 2016年 / 22卷 / 04期
关键词：
D O I：
10.1016/j.molmed.2016.02.009
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
T cells expressing chimeric antigen receptors (CARs) are a formidable platform for the study and application of synthetic biology approaches to study customized and flexible control of cellular functions. Recent reports in the journal Cell provide a new twist on combinatorial antigen targeting, profiting from the singular cleavage and signaling of the Notch receptor to conditionally express CARs.
引用
收藏
页码：271 / 273
页数：3
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