Gut dysbiosis in mice genetically selected for low antibody production

被引：0
|
作者：
da Silva Santos, Ana Carolina [1 ]
Jensen, Jose Ricardo [2 ]
de Oliveira, Silvio Luis [1 ]
Rodrigues, Josias [1 ]
机构：
[1] State Univ Sao Paulo UNESP, Inst Biosci, Dept Microbiol & Immunol, Campus Rubiao Jr, BR-18618961 Botucatu, SP, Brazil
[2] Butantan Inst, Lab Immunogenet, Ave Dr Vital Brazil 1500, BR-05503900 Sao Paulo, SP, Brazil
来源：
GUT PATHOGENS | 2017年 / 9卷
基金：
巴西圣保罗研究基金会;
关键词：
Antibody; Prevotellaceae; Bacteroidetes; Ruminococcaceae; Firmicutes; Microbiome; GRADIENT GEL-ELECTROPHORESIS; RIBOSOMAL-RNA; CROHNS-DISEASE; IMMUNE-SYSTEM; MICROBIOTA; BACTERIA; RESPONSIVENESS; COLITIS; LINES;
D O I：
10.1186/s13099-017-0193-x
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Background: Dysbiosis is linked to the cause of several human diseases, many of which having an immunity related component. This work investigated whether mice genetically selected for low or high antibody production display differences in intestinal bacterial communities, and consisted in the comparison of fecal 16SV6-V8 rDNA PCR amplicons resolved by temperature gradient gel electrophoresis (TGGE) of five each of low (LIII) and high (HIII) antibody producing mice. 16SV6 rDNA amplicons of 2 mice from each line were sequenced. Results: LIII mice were grouped in a single TGGE cluster, displayed a low a-diversity, and were distinguished by low Firmicutes/Bacteroidetes ratio. Conclusion: The results suggest that genetically driven low antibody production in mice is associated with gut dysbiosis.
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页数：6
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