Antimicrobial peptides: a new class of antimalarial drugs?

被引：66
|
作者：
Vale, Nuno [1 ]
Aguiar, Lusia [1 ]
Gomes, Paula [1 ]
机构：
[1] Univ Porto, Fac Sci, Ctr Invest Quim, Dept Chem & Biochem, P-4169007 Oporto, Portugal
来源：
FRONTIERS IN PHARMACOLOGY | 2014年 / 5卷
关键词：
AMP; amphipathic; antimalarial; antimicrobial; cationic; membranolytic; peptide; Plasmodium spp; MOSQUITO ANOPHELES-GAMBIAE; TRYPTOPHAN-RICH PEPTIDE; MALARIA VECTOR MOSQUITO; PLASMODIUM-FALCIPARUM; ESCHERICHIA-COLI; ANTIPLASMODIAL ACTIVITY; ANTIBACTERIAL PEPTIDES; ANTIPARASITIC ACTIVITY; SPOROGONIC DEVELOPMENT; PROTEIN-SYNTHESIS;
D O I：
10.3389/fphar.2014.00275
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
A range of antimicrobial peptides (AMP) exhibit activity on malaria parasites, Plasmodium spp., in their blood or mosquito stages, or both. These peptides include a diverse array of both natural and synthetic molecules varying greatly in size, charge, hydrophobicity, and secondary structure features. Along with an overview of relevant literature reports regarding AMP that display antiplasmodial activity, this review makes a few considerations about those molecules as a potential new class of antimalarial drugs.
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页数：13
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