Individual renal function in polycystic kidney disease - A follow-up study

Purpose: This study was undertaken to determine individual renal function in patients with autosomal dominant polycystic kidney disease (ADPKD), Materials and Methods: The authors initially examined (study tl) 25 patients with ADPKD (12 female, 13 male; ages 18 to 68 years), The serum creatinine concentration and glomerular filtration rate, measured by Tc-99m DTPA, were 1.5 +/- 0.56 mg/dl and 65.7 +/- 31 ml.minute(-1).1.73 m(2), respectively, Thirteen patients had a follow-up study (t2) 2 years after their initial evaluations. Individual renal function was assessed on Tc-99m DMSA renal scans. Results: The mean (+/- SD) difference between left kidney DMSA (DMSA-L) and right kidney DMSA (DMSA-R) was 7.04 % +/- 16.48%. In 20 patients (80%), the left kidney had a lower percentage contribution to the total renal function compared with the right kidney. When the results of the two studies were compared, deterioration in renal function was noted. In the tl study, the mean serum creatinine concentration and glomerular filtration rate were 1.7 mg/dl and 67.02 ml.minute(-1) 1.73 m(2) respectively, and in the t2 study these values were 2.01 mg/dl and 57.15 ml.minute(-1) 1.73 m(2), respectively. No difference, however, was found in individual renal function in the two studies. Conclusions: In patients with ADPKD, the percentage contribution of each kidney to total renal function is not equal and remains stable during the progression of renal failure.