Methods for clinical assessment of insulin sensitivity and β-cell function

被引：225
|
作者：
Pacini, G [1 ]
Mari, A [1 ]
机构：
[1] CNR, Inst Biomed Engn, Metab Modeling Unit, Padua, Italy
来源：
BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM | 2003年 / 17卷 / 03期
关键词：
insulin sensitivity; insulin resistance; insulin secretion; beta-cell function; glucose tolerance; glucose metabolism; glucose homeostasis; glucose clamp; intravenous glucose; tolerance test; minimal model; oral glucose tolerance test; methods in metabolic research; mathematical models;
D O I：
10.1016/S1521-690X(03)00042-3
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The quantitative assessment of insulin sensitivity (IS) and P-cell function (BCF) is fundamental in the study of metabolic disorders. The most relevant experimental tests and data analysis methods for assessing both IS and BCF are described and their characteristic features discussed. Advantages and limitations of each method are comparatively reviewed to help investigators choose the most suitable test for their needs. The problem of properly relating BCF to IS is also addressed. Particular attention is paid to the oral glucose tolerance test, which has recently received considerable interest. The role of mathematical models in IS and BCF assessment is also emphasized.
引用
收藏
页码：305 / 322
页数：18
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