An efficient synthesis of novel 2,4-disubstituted tetrahydroquinolines and quinolines

被引：8
|
作者：
Devakaram, Ruth [1 ]
Black, David StC [1 ]
Kumar, Naresh [1 ]
机构：
[1] Univ New S Wales, Sch Chem, Sydney, NSW 2052, Australia
来源：
TETRAHEDRON LETTERS | 2012年 / 53卷 / 18期
基金：
澳大利亚研究理事会;
关键词：
Pyrrolo[3,2,1-ij]quinoline; Indole; Isoflavonoid; Phytoestrogen; L-PROLINE; DERIVATIVES;
D O I：
10.1016/j.tetlet.2012.02.043
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A series of novel tetrahydroquinolines have been synthesized via the acid-catalyzed reaction of an aza-flavan-4-ol with a variety of reactive nucleophiles. The tetrahydroquinolines were found to undergo oxidation in the presence of iodine as catalyst to generate the corresponding novel 2,4-disubstituted quinolines. (C) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2269 / 2272
页数：4
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